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Avicenna Journal of Dental Research، جلد ۷، شماره ۱، صفحات ۰-۰
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| عنوان انگلیسی |
The Possible Role of Helicobacter pylori in the Development of Sjogren's Syndrome and Chronic Sialadenitis |
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| چکیده انگلیسی مقاله |
Conclusions Bacterial infection has been suggested in the pathogenesis of both SS and CS. In addition, H. pylori is a resident of the oral cavity, thus may be involved in the development and progression of these lesions. Hence, search for H. pylori antibody in blood of patients with SS is suggested. Background Sjogren’s syndrome (SS) is a chronic autoimmune disease characterized by lymphocytic infiltration of exocrine glands, which can be triggered by environmental factors such as viral infection. Chronic obstructive sialadenitis is the most common type of chronic sialadenitis and many different bacterial infections develop as a result of ductal obstruction. Objectives This study was conducted to assess the association of these lesions with the presence of Helicobacter pylori. Patients and Methods A total of 56 biopsies diagnosed as Sjögren's syndrome (SS) and chronic sialadenitis (CS) due to sialolithiasis in submandibular glands, sublingual and minor salivary glands were selected (56 samples as examined group and 20 samples as control group). All the paraffin blocks were cut for hematoxylin and eosin (H and E) staining to confirm the diagnoses and then the samples were prepared for immunohistochemistry (IHC) staining to detect H. pylori. Chi-squared test was used for statistical analysis. Results Chi-squared test showed a significant difference between H. pylori positivity in the groups examined (P = 0.046) and between SS group and normal tissue samples (P = 0.013). There was no significant difference between gender and H. pylori positivity in examined groups examined (P = 0.574, P = 0.543, respectively). In addition, there was no significant difference between gender and H. pylori positivity in SS group (P = 0.119, P = 0.331, respectively) also in CS group (P = 0.981, P = 0.571). |
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| نویسندگان مقاله |
علیرضا منصف اصفهانی | alireza monsef esfahani
department of pathology, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
سوسن ایرانی | soussan irani
department of oral pathology, hamadan university of medical sciences, hamadan, ir iran; department of oral pathology, hamadan university of medical sciences, p. o. box 65178-38741, hamadan, ir iran. tel 98-8118354250, fax 98-8118354220
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
شهرام ثابتی | shahram sabeti
department of pathology, loghman hospital, shahid beheshti university of medical sciences, tehran, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
فرحناز بیداری زره پوش | farahnaz bidari zerehpoush
department of pathology, loghman hospital, shahid beheshti university of medical sciences, tehran, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
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| نشانی اینترنتی |
http://www.avicennajdr.com/index.php?page=article&article_id=23212 |
| فایل مقاله |
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| کد مقاله (doi) |
10.17795/ajdr-23212 |
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
1 |
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