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Avicenna Journal of Dental Research، جلد ۷، شماره ۱، صفحات ۰-۰
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| عنوان فارسی |
Comparison of Mast Cell Presence in Inflammatory Periapical Lesions Including Periapical Cyst and Granuloma Using Cd۱۱۷ (C-KIT) |
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| چکیده فارسی مقاله |
Background Periapical lesions are induced in response to injuries to periapical tissues, which are generally the result of infections within the root canal. Mast cells actively participate to the inflammatory infiltration of periapical granulomas and cysts. Objectives The aim of this study was to detect and compare the presence of mast cells in inflammatory periapical lesions, including cysts and granulomas. Materials and Methods In this cross-sectional study, 26 samples of inflammatory periapical lesions (17 cysts and nine granulomas) were stained with an immunohistochemical technique using CD117 (C-KIT) antibody to detect mast cells. Then, mast cell count (the number of mast cells in 0.2 mm2) and the intensity of mast cell staining were determined by two board certified pathologists. Fisher exact test and t-test were used for statistical analysis, with P < 0.05 for statistical significance. Conclusions According to the results of this study, it appears that mast cells are present in all the investigated inflammatory periapical lesions and might play a role in the pathogenesis of these lesions. Results Although mast cells were observed in all samples, there were more numerous in periapical granulomas compared to periapical cysts, with no statistically significant difference (P = 0.076). The results also demonstrated that the staining in periapical cysts and granulomas were of strong and moderate intensity, respectively, without any significant difference (P = 0.411). |
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| کلیدواژه‌های فارسی مقاله |
Mast Cells،Radicular Cyst،Periapical Granuloma،CD117 Antigen |
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| عنوان انگلیسی |
Comparison of Mast Cell Presence in Inflammatory Periapical Lesions Including Periapical Cyst and Granuloma Using Cd117 (C-KIT) |
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| چکیده انگلیسی مقاله |
Background Periapical lesions are induced in response to injuries to periapical tissues, which are generally the result of infections within the root canal. Mast cells actively participate to the inflammatory infiltration of periapical granulomas and cysts. Objectives The aim of this study was to detect and compare the presence of mast cells in inflammatory periapical lesions, including cysts and granulomas. Materials and Methods In this cross-sectional study, 26 samples of inflammatory periapical lesions (17 cysts and nine granulomas) were stained with an immunohistochemical technique using CD117 (C-KIT) antibody to detect mast cells. Then, mast cell count (the number of mast cells in 0.2 mm2) and the intensity of mast cell staining were determined by two board certified pathologists. Fisher exact test and t-test were used for statistical analysis, with P < 0.05 for statistical significance. Conclusions According to the results of this study, it appears that mast cells are present in all the investigated inflammatory periapical lesions and might play a role in the pathogenesis of these lesions. Results Although mast cells were observed in all samples, there were more numerous in periapical granulomas compared to periapical cysts, with no statistically significant difference (P = 0.076). The results also demonstrated that the staining in periapical cysts and granulomas were of strong and moderate intensity, respectively, without any significant difference (P = 0.411). |
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| کلیدواژه‌های انگلیسی مقاله |
Mast Cells,Radicular Cyst,Periapical Granuloma,CD117 Antigen |
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| نویسندگان مقاله |
ستاره شجاعی | setareh shojaei
department of oral and maxillofacial pathology, faculty of dentistry, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
شکوفه جمشیدی | shokoofeh jamshidi
department of oral and maxillofacial pathology, dental research center, faculty of dentistry, hamadan university of medical sciences, hamadan, ir iran; department of oral and maxillofacial pathology, dental research center, faculty of dentistry, hamadan university of medical sciences, hamadan, p.o. box 65176-59114, ir iran. tel 98-8138354140, fax 98-8138381085
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
جواد فردمال | javad faradmal
department of biostatistics and epidemiology, modeling of noncommunicable diseases research center, school of public health, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
خدیجه بیگلری | khadije biglari
faculty of dentistry, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
سعیده خواجه احمدی | saeedeh khajeh ahmadi
department of oral and maxillofacial pathology, dental research center, faculty of dentistry, mashhad university of medical sciences, mashhad, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
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| نشانی اینترنتی |
http://www.avicennajdr.com/index.php?page=article&article_id=24679 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
10.17795/ajdr-24679 |
| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
1 |
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