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Avicenna Journal of Medical Biochemistry، جلد ۴، شماره ۱، صفحات ۰-۰
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| عنوان فارسی |
The Effects of the Synthetic Antioxidant, Tempol, on Serum Glucose and Lipid Profile of Diabetic and Non-Diabetic Rats |
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| چکیده فارسی مقاله |
Conclusions It can be concluded that tempol can improve dyslipidemia and may decrease hyperglycemia in diabetes. It seems that antioxidants such as tempol can improve dyslipidemia and may decrease hyperglycemia in diabetes. Results The blood glucose level increased following diabetes induction. The level of blood glucose in the diabetic receiving tempol group decreased compared to the control diabetic group. The comparison of LDL, VLDL, cholesterol, triglyceride, HbA1c and coronary risk index among experimental groups indicated the increase of these factors in the diabetic group. High-density lipoprotein in the diabetic groups was lower than the other groups. Objectives The aim of the present study was to evaluate the effect of the synthetic antioxidant, tempol, on blood lipid profiles and glucose levels in healthy and diabetic rats. Materials and Methods Adult Wistar rats were randomly divided to four experimental groups including, healthy control, diabetic control, diabetic receiving tempol and healthy receiving tempol groups. Diabetes was induced by injection of streptozotocin (60 mg/kg, Intraperitoneally (IP)). The rats were then fed saline or tempol (30 mg/kg) by gavage for 60 days. Blood samples were collected by cardiac puncture. Next, glucose, high-density lipoprotein (HDL), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), cholesterol, triglyceride and HbA1c were measured by specific kits. Also, the coronary risk index was calculated. Background Hyperlipidemia and low antioxidant levels is one the diabetes side effects. Some studies have indicated the possible effects of nutrients on the improvement of hyperlipidemia, by their antioxidants ingredients. |
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| کلیدواژه‌های فارسی مقاله |
Tempol،Lipid Profiles،Diabetes،Rat |
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| عنوان انگلیسی |
The Effects of the Synthetic Antioxidant, Tempol, on Serum Glucose and Lipid Profile of Diabetic and Non-Diabetic Rats |
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| چکیده انگلیسی مقاله |
Conclusions It can be concluded that tempol can improve dyslipidemia and may decrease hyperglycemia in diabetes. It seems that antioxidants such as tempol can improve dyslipidemia and may decrease hyperglycemia in diabetes. Results The blood glucose level increased following diabetes induction. The level of blood glucose in the diabetic receiving tempol group decreased compared to the control diabetic group. The comparison of LDL, VLDL, cholesterol, triglyceride, HbA1c and coronary risk index among experimental groups indicated the increase of these factors in the diabetic group. High-density lipoprotein in the diabetic groups was lower than the other groups. Objectives The aim of the present study was to evaluate the effect of the synthetic antioxidant, tempol, on blood lipid profiles and glucose levels in healthy and diabetic rats. Materials and Methods Adult Wistar rats were randomly divided to four experimental groups including, healthy control, diabetic control, diabetic receiving tempol and healthy receiving tempol groups. Diabetes was induced by injection of streptozotocin (60 mg/kg, Intraperitoneally (IP)). The rats were then fed saline or tempol (30 mg/kg) by gavage for 60 days. Blood samples were collected by cardiac puncture. Next, glucose, high-density lipoprotein (HDL), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), cholesterol, triglyceride and HbA1c were measured by specific kits. Also, the coronary risk index was calculated. Background Hyperlipidemia and low antioxidant levels is one the diabetes side effects. Some studies have indicated the possible effects of nutrients on the improvement of hyperlipidemia, by their antioxidants ingredients. |
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| کلیدواژه‌های انگلیسی مقاله |
Tempol,Lipid Profiles,Diabetes,Rat |
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| نویسندگان مقاله |
سیامک شهیدی | siamak shahidi
neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran; neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran. tel 98-8138380462, fax 98-8138380208
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
زهرا جبارپور | zahra jabbarpour
department of physiology, school of medicine, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
مسعود سعیدی جم | masoud saidijam
research center for molecular medicine, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
رسول اسماعیلی | rasoul esmaeili
department of physiology, school of medicine, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
علیرضا کمکی | alireza komaki
neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
نسرین هاشمی فیروزی | nasrin hashemi firouzi
neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
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| نشانی اینترنتی |
http://www.avicennajb.com/index.php?page=article&article_id=31043 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
10.17795/ajmb-31043 |
| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
research-article |
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