Avicenna Journal of Medical Biochemistry، جلد ۴، شماره ۱، صفحات ۰-۰
عنوان فارسی Association of Seminal Plasma Total Antioxidant Capacity and Malondialdehyde Levels With Sperm Parameters in Infertile Men With Varicocele
چکیده فارسی مقاله Conclusions Our findings indicated that oxidative stress could play an essential role in male infertility caused by varicocele and may impair spermatogenesis leading to infertility. Objectives In the current study, we aimed to assess the TAC (total antioxidant capacity) and MDA (malondialdehyde) as stress oxidative markers in infertile men with varicocele and fertile men, and moreover, their correlation with sperm parameters. Patients and Methods This case control study was performed on 43 infertile men with varicocele and 46 men with proven fertility. The ferric reducing ability of plasma (FRAP) and thiobarbituric acid (TBA) reaction methods were used for seminal plasma TAC and MDA assay, respectively. Results Lower TAC levels (1.7 ± 0.2 vs. 1.3 ± 0.4 mmol/L, P = 0.0004) and higher MDA levels (2.5 ± 1.1 vs. 5.8 ± 1.9 mmol/L, P < 0.0001) were observed in infertile men with varicocele compared to fertile men. There was no correlation between TAC and MDA in fertile men (r = 0.02, P = 0.9), however, a negative correlation was found between TAC and MDA levels in varicocele infertile men (r = −0.44, P = 0.003). Moreover, a positive correlation was found between sperm count and sperm motility with TAC levels in varicocele infertile men (r = 0.4, P = 0.02 and r = 0.6, P < 0.0001, respectively). There was a correlation between sperm motility and TAC levels in fertile men (r = 0.5, P = 0.001), but other parameters did not correlate with TAC in this group. A negative correlation was shown between semen volume, sperm count, total sperm, sperm motility, and sperm morphology with MDA levels in varicocele infertile men (r = 0.3, P = 0.045; r = −0.4, P = 0.009; r = −0.5, P = 0.002; r = −0.5, P = 0.001 and r = −0.4, P = 0.008, respectively). There was no correlation between these parameters and MDA in fertile men. Background Varicocele is one of the most common reasons for male infertility and could impair spermatogenesis through mechanisms that are not well known. Recently, oxidative stress has been introduced as a major reason for male infertility caused by varicocele.
کلیدواژه‌های فارسی مقاله Malondialdehyde،Semen،Total Antioxidant Capacity،Varicocele
عنوان انگلیسی Association of Seminal Plasma Total Antioxidant Capacity and Malondialdehyde Levels With Sperm Parameters in Infertile Men With Varicocele
چکیده انگلیسی مقاله Conclusions Our findings indicated that oxidative stress could play an essential role in male infertility caused by varicocele and may impair spermatogenesis leading to infertility. Objectives In the current study, we aimed to assess the TAC (total antioxidant capacity) and MDA (malondialdehyde) as stress oxidative markers in infertile men with varicocele and fertile men, and moreover, their correlation with sperm parameters. Patients and Methods This case control study was performed on 43 infertile men with varicocele and 46 men with proven fertility. The ferric reducing ability of plasma (FRAP) and thiobarbituric acid (TBA) reaction methods were used for seminal plasma TAC and MDA assay, respectively. Results Lower TAC levels (1.7 ± 0.2 vs. 1.3 ± 0.4 mmol/L, P = 0.0004) and higher MDA levels (2.5 ± 1.1 vs. 5.8 ± 1.9 mmol/L, P < 0.0001) were observed in infertile men with varicocele compared to fertile men. There was no correlation between TAC and MDA in fertile men (r = 0.02, P = 0.9), however, a negative correlation was found between TAC and MDA levels in varicocele infertile men (r = −0.44, P = 0.003). Moreover, a positive correlation was found between sperm count and sperm motility with TAC levels in varicocele infertile men (r = 0.4, P = 0.02 and r = 0.6, P < 0.0001, respectively). There was a correlation between sperm motility and TAC levels in fertile men (r = 0.5, P = 0.001), but other parameters did not correlate with TAC in this group. A negative correlation was shown between semen volume, sperm count, total sperm, sperm motility, and sperm morphology with MDA levels in varicocele infertile men (r = 0.3, P = 0.045; r = −0.4, P = 0.009; r = −0.5, P = 0.002; r = −0.5, P = 0.001 and r = −0.4, P = 0.008, respectively). There was no correlation between these parameters and MDA in fertile men. Background Varicocele is one of the most common reasons for male infertility and could impair spermatogenesis through mechanisms that are not well known. Recently, oxidative stress has been introduced as a major reason for male infertility caused by varicocele.
کلیدواژه‌های انگلیسی مقاله Malondialdehyde,Semen,Total Antioxidant Capacity,Varicocele
نویسندگان مقاله سعیده سلیمی | saeedeh salimi
cellular and molecular research center, zahedan university of medical sciences, zahedan, ir iran; department of clinical biochemistry, school of medicine, zahedan university of medical sciences, zahedan, ir iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)

فرامرز فاضلی | faramarz fazeli
department of urology, school of medicine, zahedan university of medical sciences, zahedan, ir iran; department of urology, school of medicine, zahedan university of medical sciences, zahedan, ir iran. tel 98-5433425728, fax 98-5433425728

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)

پریا خسروی | paria khosravi
department of urology, school of medicine, zahedan university of medical sciences, zahedan, ir iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)

سیما نبی زاده | sima nabizadeh
department of english language, school of medicine, zahedan university of medical sciences, zahedan, ir iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)

نشانی اینترنتی http://www.avicennajb.com/index.php?page=article&article_id=33540
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کد مقاله (doi) 10.17795/ajmb.33540
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