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Avicenna Journal of Medical Biochemistry، جلد ۴، شماره ۱، صفحات ۰-۰
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| عنوان فارسی |
The in Silico Approach to Identify a Unique Plant-Derived Inhibitor Against E۶ and E۷ Oncogenic Proteins of High-Risk Human Papillomavirus ۱۶ and ۱۸ |
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| چکیده فارسی مقاله |
Materials and Methods Twelve natural compounds jaceosidin, withaferin A, curcumin, epigallocatechin-3-gallate (EGCG), artemisinin, gingerol, ursolic acid, ferulic acid, berberin, silymarin, resveratrol, and indol-3-carbinol were docked against E6 and E7 oncoproteins of high-risk HPV types 16 and 18 using a protein-ligand docking software called AutoDock4.2. Results Out of these 12 natural compounds, withaferin A was found to inhibit all four oncoproteins with minimum binding energy. Conclusions These in silico findings indicate that withaferin A may be used as a common drug for cervical cancer caused by high-risk HPV types, perhaps by restoring the normal functions of tumor suppressor proteins. Objectives The goal of this study is to identify unique plant-originated compounds to utilize in order to combat the high-risk human papillomavirus oncoproteins using docking measures. Background Globally, the human papillomavirus (HPV) remains the foremost cause of cancer mortality among women. There is a need to identify natural anti-cancerous compounds that can fight against life-threatening infections by HPV. Various kinds of natural plant-originated compounds have been used in the traditional system of medicine for cancer therapy. Different studies have reported the effective inhibition of HPV infection enacted by certain natural compounds. Out of all the different HPV types, HPV-16 and 18 are the ones mainly associated with causing cervical cancer; furthermore, the E6 and E7 oncoproteins of these two high-risk HPV types typically interact with tumor protein 53 (p53) and retinoblastoma tumor suppressor proteins (pRb) of human host which consequent to cancer formation. |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
The in Silico Approach to Identify a Unique Plant-Derived Inhibitor Against E6 and E7 Oncogenic Proteins of High-Risk Human Papillomavirus 16 and 18 |
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| چکیده انگلیسی مقاله |
Materials and Methods Twelve natural compounds jaceosidin, withaferin A, curcumin, epigallocatechin-3-gallate (EGCG), artemisinin, gingerol, ursolic acid, ferulic acid, berberin, silymarin, resveratrol, and indol-3-carbinol were docked against E6 and E7 oncoproteins of high-risk HPV types 16 and 18 using a protein-ligand docking software called AutoDock4.2. Results Out of these 12 natural compounds, withaferin A was found to inhibit all four oncoproteins with minimum binding energy. Conclusions These in silico findings indicate that withaferin A may be used as a common drug for cervical cancer caused by high-risk HPV types, perhaps by restoring the normal functions of tumor suppressor proteins. Objectives The goal of this study is to identify unique plant-originated compounds to utilize in order to combat the high-risk human papillomavirus oncoproteins using docking measures. Background Globally, the human papillomavirus (HPV) remains the foremost cause of cancer mortality among women. There is a need to identify natural anti-cancerous compounds that can fight against life-threatening infections by HPV. Various kinds of natural plant-originated compounds have been used in the traditional system of medicine for cancer therapy. Different studies have reported the effective inhibition of HPV infection enacted by certain natural compounds. Out of all the different HPV types, HPV-16 and 18 are the ones mainly associated with causing cervical cancer; furthermore, the E6 and E7 oncoproteins of these two high-risk HPV types typically interact with tumor protein 53 (p53) and retinoblastoma tumor suppressor proteins (pRb) of human host which consequent to cancer formation. |
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| نویسندگان مقاله |
satish کومار | satish kumar
bioinformatics and biochemistry centre, mahatma gandhi institute of medical sciences, maharashtra university of health sciences, maharashtra, india; bioinformatics and biochemistry centre, mahatma gandhi institute of medical sciences, maharashtra university of health sciences, maharashtra, india. tel 91-7152284679, fax 91-7152284038
lingaraja جینا | lingaraja jena
bioinformatics and biochemistry centre, mahatma gandhi institute of medical sciences, maharashtra university of health sciences, maharashtra, india
maheswata sahoo | maheswata sahoo
bioinformatics and biochemistry centre, mahatma gandhi institute of medical sciences, maharashtra university of health sciences, maharashtra, india
tapaswini nayak | tapaswini nayak
bioinformatics and biochemistry centre, mahatma gandhi institute of medical sciences, maharashtra university of health sciences, maharashtra, india
kanchan mohod | kanchan mohod
bioinformatics and biochemistry centre, mahatma gandhi institute of medical sciences, maharashtra university of health sciences, maharashtra, india
سانگیتا daf | sangeeta daf
datta meghe institute of medical sciences, deemed university, maharashtra, india
ashok k ورما | ashok k varma
advanced centre for treatment, research and education in cancer, university of mumbai, navi mumbai, india
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| نشانی اینترنتی |
http://www.avicennajb.com/index.php?page=article&article_id=33958 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
10.17795/ajmb-33958 |
| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
research-article |
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