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Avicenna Journal of Medical Biochemistry، جلد ۳، شماره ۲، صفحات ۰-۰
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| عنوان فارسی |
Garlic Powder Effect on Plasma Renin Activity, and Cardiovascular Effects of Intravenous Angiotensin I and Angiotensin II in Normotensive and Hypertensive Male Rats |
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| چکیده فارسی مقاله |
Conclusions Garlic powder consumption can reduce blood pressure, yet in this model, it did not have an effect on the interaction between renin angiotensin system and nitric oxide inhibition. Results At the beginning and at the end of experiments, systolic blood pressure was higher in the hypertensive groups than the normotensive group. However, at the end of the study, diastolic blood pressure and mean arterial pressure were higher in the hypertensive groups than the normotensive group. Angiotensin I level was low in the normotensive group whereas plasma renin activity was high in the hypertensive group. After different doses of injection of angiotensin I and angiotensin II, mean arterial pressure was significantly increased in the normotensive-garlic and the hypertensive-garlic groups, respectively. By using captopril, mean arterial pressure and its changes were not significant after injection of different doses of angiotensin I in different groups. Objectives The aim of the this study was to investigate the effect of consumption of garlic powder on blood pressure and renin angiotensin system in a nitric oxide deficiency hypertension model in male rats. Materials and Methods In this study, thirty-two adult male Wistar rats (200 - 250 g) were randomly divided to four groups as follows: normotensive, normotensive-garlic, hypertensive and hypertensive-garlic. Oral N-nitro-L-arginine methyl ester (L-NAME) was used to induce hypertension. Normotensive-garlic and hypertensive-garlic groups were fed 900 mg of garlic powder daily by oral gavage for forty-five days. At the beginning of the experiments, systolic blood pressure was measured. Immediately after the end of the experimental procedure animals were anaesthetized by pentobarbital, blood samples were collected and, after injection of angiotensin I, angiotensin II and captopril, blood pressure was re-measured. Plasma renin activity was also measured. Background Hypertension is amongst major health issues in developed countries, which results in cardiovascular morbidity and mortality. Garlic plays an important role in the reduction of hypertension. |
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| کلیدواژه‌های فارسی مقاله |
Blood Pressure،Garlic،Renin-Angiotensin System،Rats |
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| عنوان انگلیسی |
Garlic Powder Effect on Plasma Renin Activity, and Cardiovascular Effects of Intravenous Angiotensin I and Angiotensin II in Normotensive and Hypertensive Male Rats |
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| چکیده انگلیسی مقاله |
Conclusions Garlic powder consumption can reduce blood pressure, yet in this model, it did not have an effect on the interaction between renin angiotensin system and nitric oxide inhibition. Results At the beginning and at the end of experiments, systolic blood pressure was higher in the hypertensive groups than the normotensive group. However, at the end of the study, diastolic blood pressure and mean arterial pressure were higher in the hypertensive groups than the normotensive group. Angiotensin I level was low in the normotensive group whereas plasma renin activity was high in the hypertensive group. After different doses of injection of angiotensin I and angiotensin II, mean arterial pressure was significantly increased in the normotensive-garlic and the hypertensive-garlic groups, respectively. By using captopril, mean arterial pressure and its changes were not significant after injection of different doses of angiotensin I in different groups. Objectives The aim of the this study was to investigate the effect of consumption of garlic powder on blood pressure and renin angiotensin system in a nitric oxide deficiency hypertension model in male rats. Materials and Methods In this study, thirty-two adult male Wistar rats (200 - 250 g) were randomly divided to four groups as follows: normotensive, normotensive-garlic, hypertensive and hypertensive-garlic. Oral N-nitro-L-arginine methyl ester (L-NAME) was used to induce hypertension. Normotensive-garlic and hypertensive-garlic groups were fed 900 mg of garlic powder daily by oral gavage for forty-five days. At the beginning of the experiments, systolic blood pressure was measured. Immediately after the end of the experimental procedure animals were anaesthetized by pentobarbital, blood samples were collected and, after injection of angiotensin I, angiotensin II and captopril, blood pressure was re-measured. Plasma renin activity was also measured. Background Hypertension is amongst major health issues in developed countries, which results in cardiovascular morbidity and mortality. Garlic plays an important role in the reduction of hypertension. |
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| کلیدواژه‌های انگلیسی مقاله |
Blood Pressure,Garlic,Renin-Angiotensin System,Rats |
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| نویسندگان مقاله |
علی اصغر وحیدی نیا | aliasghar vahidinia
department of nutrition sciences, school of medicine, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
بهنام حشمتیان | behnam heshmatian
department of physiology, school of medicine, urmia university of medical sciences, urmia, ir iran; department of physiology, school of medicine, hamadan university of medical sciences, hamadan, ir iran. tel 98-8138380208, e-mail ; behnam heshmatian, department of physiology, school of medicine, urmia university of medical sciences, urmia, ir iran. tel 98-8138380464, fax 98-8138380208
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
ایرج صالحی | iraj salehi
chronic diseases home care research center and department of physiology, school of paramedicine, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
محمد زارعی | mohammad zarei
department of physiology, school of medicine, hamadan university of medical sciences, hamadan, ir iran; department of physiology, school of medicine, hamadan university of medical sciences, hamadan, ir iran. tel 98-8138380208, e-mail ; behnam heshmatian, department of physiology, school of medicine, urmia university of medical sciences, urmia, ir iran. tel 98-8138380464, fax 98-8138380208
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
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| نشانی اینترنتی |
http://www.avicennajb.com/index.php?page=article&article_id=28581 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
10.17795/ajmb-28581 |
| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
research-article |
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