| چکیده فارسی مقاله |
Background The malonyl-CoA decarboxylase (MCD, EC.4.1.1.9) enzyme regulates malonyl-CoA levels. The effect of aerial parts extracts of Urtica dioica (UD) on MCD is poorly understood. Objectives The present experiment was undertaken to evaluate the effect of UD aerial parts extracts on MCD level. Materials and Methods In this experimental study, two groups of rats were used: normal and hyperglycemic group. Then UD aerial parts extracts (5 mg /500 µL) administrated to the hyperglycemic group of rats and finally, the MCD and insulin levels were measured in both groups. Results Interestingly, we observed that the UD aerial parts extracts powder caused a significant (P < 0.05) increase in insulin level during the experiment, from the base level of 0.36 ± 0.07 μg/L to the peak value of 0.52 ± 0.15 μg/L. Also, it caused a significant (P < 0.05) decrease in MCD level, from the base level of 29.68 ±1.29 pg/mL to the bottom value of 22.12 ± 2.41 pg/mL. Conclusions The results of the present study indicate that UD aerial part extracts would decrease MCD level in hyperglycemic rats. |
| چکیده انگلیسی مقاله |
Background The malonyl-CoA decarboxylase (MCD, EC.4.1.1.9) enzyme regulates malonyl-CoA levels. The effect of aerial parts extracts of Urtica dioica (UD) on MCD is poorly understood. Objectives The present experiment was undertaken to evaluate the effect of UD aerial parts extracts on MCD level. Materials and Methods In this experimental study, two groups of rats were used: normal and hyperglycemic group. Then UD aerial parts extracts (5 mg /500 µL) administrated to the hyperglycemic group of rats and finally, the MCD and insulin levels were measured in both groups. Results Interestingly, we observed that the UD aerial parts extracts powder caused a significant (P < 0.05) increase in insulin level during the experiment, from the base level of 0.36 ± 0.07 μg/L to the peak value of 0.52 ± 0.15 μg/L. Also, it caused a significant (P < 0.05) decrease in MCD level, from the base level of 29.68 ±1.29 pg/mL to the bottom value of 22.12 ± 2.41 pg/mL. Conclusions The results of the present study indicate that UD aerial part extracts would decrease MCD level in hyperglycemic rats. |
| نویسندگان مقاله |
دردی قوجق | durdi qujeq
cellular and molecular biology research center, department of biochemistry and biophysics, faculty of medicine, babol university of medical sciences, babol, ir iran; department of biochemistry and biophysics, faculty of medicine, babol university of medical sciences, babol, ir iran; cellular and molecular biology research center, department of biochemistry and biophysics, faculty of medicine, babol university of medical sciences, babol, ir iran. tel 98-1112229591-5, fax 98-1112226109
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)
محسن تاتار | mohsen tatar
department of biochemistry and biophysics, faculty of medicine, babol university of medical sciences, babol, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)
فریده فیضی | farideh feizi
department of anatomical sciences, faculty of medicine, babol university of medical sciences, babol, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)
هادی پارسیان | hadi parsian
cellular and molecular biology research center, department of biochemistry and biophysics, faculty of medicine, babol university of medical sciences, babol, ir iran; department of biochemistry and biophysics, faculty of medicine, babol university of medical sciences, babol, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)
سهراب حلال خور | sohrab halalkhor
department of biochemistry and biophysics, faculty of medicine, babol university of medical sciences, babol, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)
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