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Avicenna Journal of Medical Biochemistry، جلد ۲، شماره ۲، صفحات ۰-۰
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| عنوان فارسی |
Effects of Skin Penetration Enhancers in Topical Antiaging Products Containing α-HydroxyAcids and Hyaluronic Acid |
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| چکیده فارسی مقاله |
Conclusions The most effective enhancer for AHA and HA were liquid paraffin and glycerol, respectively. The most effective surfactant for both AHA and HA was Tween 80. The effects of the enhancers were increased by prolonging the exposure time. Results After 1.5 and 12 hours, the maximum permeated amount of AHA were 89.8 and 342.5 mg, respectively, which related to the formulations with liquid paraffin. After 1.5 and 12 hours, the maximum permeated amount of HA were 57.3 and 70.6 mg, respectively, which related to the formulations with glycerol. Materials and Methods A total of 42 different formulations containing AHA or HA as the active ingredient and a solvent or surfactant as the enhancer were prepared. The experiments for determination of transdermal absorption of AHA or HA for each formulation were performed using a diffusion cell and a slice of chicken skin as model at 32℃. After 1.5 or 12 hours, samples from the medium were collected and analyzed for AHA or HA concentration. Background Transdermal drug delivery has several advantages and has been vastly investigated over the last decades. Chemical enhancers improve the quantity of drug penetration through the skin. Objectives In this study, some conventional solvents and surfactants were used as enhancers to promote dermal penetration of α-hydroxyacids (AHA) and hyaluronic acid (HA). |
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| کلیدواژه‌های فارسی مقاله |
Acids،Hyaluronic Acid،Solvents،Surfactants |
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| عنوان انگلیسی |
Effects of Skin Penetration Enhancers in Topical Antiaging Products Containing α-HydroxyAcids and Hyaluronic Acid |
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| چکیده انگلیسی مقاله |
Conclusions The most effective enhancer for AHA and HA were liquid paraffin and glycerol, respectively. The most effective surfactant for both AHA and HA was Tween 80. The effects of the enhancers were increased by prolonging the exposure time. Results After 1.5 and 12 hours, the maximum permeated amount of AHA were 89.8 and 342.5 mg, respectively, which related to the formulations with liquid paraffin. After 1.5 and 12 hours, the maximum permeated amount of HA were 57.3 and 70.6 mg, respectively, which related to the formulations with glycerol. Materials and Methods A total of 42 different formulations containing AHA or HA as the active ingredient and a solvent or surfactant as the enhancer were prepared. The experiments for determination of transdermal absorption of AHA or HA for each formulation were performed using a diffusion cell and a slice of chicken skin as model at 32℃. After 1.5 or 12 hours, samples from the medium were collected and analyzed for AHA or HA concentration. Background Transdermal drug delivery has several advantages and has been vastly investigated over the last decades. Chemical enhancers improve the quantity of drug penetration through the skin. Objectives In this study, some conventional solvents and surfactants were used as enhancers to promote dermal penetration of α-hydroxyacids (AHA) and hyaluronic acid (HA). |
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| کلیدواژه‌های انگلیسی مقاله |
Acids,Hyaluronic Acid,Solvents,Surfactants |
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| نویسندگان مقاله |
نرگس شکری | narges shokri
department of pharmaceutics, faculty of pharmacy, hamadan university of medical sciences, hamadan, ir iran; department of pharmaceutics, faculty of pharmacy, hamadan university of medical sciences, hamadan, ir iran. tel 98-8118381591, fax 98-8118380031
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
حمید اکبری جور | hamid akbari javar
department of pharmaceutics, faculty of pharmacy, tehran university of medical sciences, tehran, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
روژین قادرمزی | rozhin ghadermazi
department of pharmaceutics, faculty of pharmacy, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
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| نشانی اینترنتی |
http://www.avicennajb.com/index.php?page=article&article_id=18611 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
10.17795/ajmb-18611 |
| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
research-article |
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