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Avicenna Journal of Neuro Psycho Phyisology، جلد ۳، شماره ۲، صفحات ۰-۰
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| عنوان فارسی |
Alpha-Pinene as the Main Component of Ducrosia anethifolia (Boiss) Essential Oil is Responsible for its Effect on Locomotor Activity in Rats |
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| چکیده فارسی مقاله |
Background Ducrosia anethifolia (DA) is a medicinal plant traditionally used to treat a wide spectrum of illnesses. DA contains a series of antioxidant compounds, including alpha-pinene, which give it a sedative and relaxing effect. In spite of these effects of DA, the effects of DA essential oil on anxiety and locomotor activity in open field tests have not yet been studied. In the present study, the effects of DA essential oil and its main component of alpha-pinene on locomotor activity and anxiety were studied using open field tests. Objectives The purpose of this study was to investigate the effects of DA essential oil and its main component, alpha-pinene, on locomotor activity and anxiety behaviors using open field and antioxidant capacity tests in Wistar rats. Methods Sixty-three adult male Wistar rats (weighing 200 - 250 g) were divided into 9 groups: control, positive control (diazepam), essential oil treated groups (25, 50, 100, 200, and 500 mg/kg administered intraperitoneally, (i.p.)) and alpha-pinene groups (0.2 and 0.4 mg/kg, i.p.). For precisely 30 minutes after each injection in all groups, open field tests were used to assess behaviors such as rearing, line crossing, walling, grooming, and stretched attend posturing. In addition, oxidant and antioxidant parameters (malondialdehyde [MDA] and catalase [CAT]) were assessed in the rats’ temporal lobes. Results DA (200 and 500 mg/kg doses) and alpha-pinene (0.2 and 0.4 mg/kg doses) significantly reduced locomotor activity, whereas doses of 25, 50, and 100 mg/kg of DA failed to show such an effect. Treatment with DA and alpha-pinene resulted in a significant decrease in MDA levels and a significant increase in CAT activity in comparison to controls. Conclusions The results of this study suggest that the main component of DA (alpha-pinene) is responsible for DA’s ability to reduce locomotor activity and anxiety, which is indicative of CNS depressant activity. Moreover, it is possible that some of the motor suppression and sedation effects of the alpha-pinene in DA are due to the antioxidant capacity of this substance. However, further research and clinical evaluations are necessary to isolate and identify the other substances responsible for these activities in DA. |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Alpha-Pinene as the Main Component of Ducrosia anethifolia (Boiss) Essential Oil is Responsible for its Effect on Locomotor Activity in Rats |
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| چکیده انگلیسی مقاله |
Background Ducrosia anethifolia (DA) is a medicinal plant traditionally used to treat a wide spectrum of illnesses. DA contains a series of antioxidant compounds, including alpha-pinene, which give it a sedative and relaxing effect. In spite of these effects of DA, the effects of DA essential oil on anxiety and locomotor activity in open field tests have not yet been studied. In the present study, the effects of DA essential oil and its main component of alpha-pinene on locomotor activity and anxiety were studied using open field tests. Objectives The purpose of this study was to investigate the effects of DA essential oil and its main component, alpha-pinene, on locomotor activity and anxiety behaviors using open field and antioxidant capacity tests in Wistar rats. Methods Sixty-three adult male Wistar rats (weighing 200 - 250 g) were divided into 9 groups: control, positive control (diazepam), essential oil treated groups (25, 50, 100, 200, and 500 mg/kg administered intraperitoneally, (i.p.)) and alpha-pinene groups (0.2 and 0.4 mg/kg, i.p.). For precisely 30 minutes after each injection in all groups, open field tests were used to assess behaviors such as rearing, line crossing, walling, grooming, and stretched attend posturing. In addition, oxidant and antioxidant parameters (malondialdehyde [MDA] and catalase [CAT]) were assessed in the rats’ temporal lobes. Results DA (200 and 500 mg/kg doses) and alpha-pinene (0.2 and 0.4 mg/kg doses) significantly reduced locomotor activity, whereas doses of 25, 50, and 100 mg/kg of DA failed to show such an effect. Treatment with DA and alpha-pinene resulted in a significant decrease in MDA levels and a significant increase in CAT activity in comparison to controls. Conclusions The results of this study suggest that the main component of DA (alpha-pinene) is responsible for DA’s ability to reduce locomotor activity and anxiety, which is indicative of CNS depressant activity. Moreover, it is possible that some of the motor suppression and sedation effects of the alpha-pinene in DA are due to the antioxidant capacity of this substance. However, further research and clinical evaluations are necessary to isolate and identify the other substances responsible for these activities in DA. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
مهناز زامیاد | mahnaz zamyad
faculty of sciences, department of biology, shahid bahonar university of kerman, kerman, ir iran
سازمان اصلی تایید شده: دانشگاه شهید باهنر (Shahid bahonar university)
مهدی عباس نژاد | mehdi abasnejad
faculty of sciences, department of biology, shahid bahonar university of kerman, kerman, ir iran; faculty of sciences, department of biology, shahid bahonar university of kerman, p. o. box 76135133, kerman, ir iran. fax 98-3433257432
سازمان اصلی تایید شده: دانشگاه شهید باهنر (Shahid bahonar university)
سعید اسماعیلی ماهانی | saeed esmaeili mahani
faculty of sciences, department of biology, shahid bahonar university of kerman, kerman, ir iran; laboratory of molecular neuroscience, kerman neuroscience research center, kerman university of medical sciences, kerman, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)
علی مصطفوی | ali mostafavi
faculty of sciences, department of chemistry, shahid bahonar university of kerman. kerman, ir iran
سازمان اصلی تایید شده: دانشگاه شهید باهنر (Shahid bahonar university)
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| نشانی اینترنتی |
http://www.avicennajnpp.com/index.php?page=article&article_id=38787 |
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| کد مقاله (doi) |
10.17795/ajnpp-38787 |
| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
research-article |
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