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Avicenna Journal of Neuro Psycho Phyisology، جلد ۲، شماره ۱، صفحات ۰-۰
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| عنوان فارسی |
The Antinociceptive Effects of Hydroalcoholic Extract of Bryonia dioica in Male Rats |
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| چکیده فارسی مقاله |
Conclusions The experimental data verified that HEBD leaves displayed remarkable antinociceptive activity. Furthermore, the nonselective opioid receptor antagonist, naloxone blocked the antinociceptive effect of the extract in all tests, suggesting that HEBD may act both at peripheral and central levels. Results Using writhing, tail-flick, and formalin tests, dramatic antinociceptive effects were observed for HEBD at the dose of 300 mg/kg with P < 0.01. The results of data analysis also revealed that there was no significant difference between indomethacin and dose of 300 mg/kg of extract in formalin test. LD50 of the plant was 4200 mg/kg. Materials and Methods In this experimental study, 42 adult male rats were divided into 7 groups: control, HEBD (80, 100, and 300 mg/kg, ip), morphine (1 mg/kg, ip), indomethacin (1 mg/kg, ip), and naloxone (1 mg/kg ip). In order to assess the analgesic effects of the extract, writhing, tail-flick, and formalin tests were used. Also, Tukey post hoc and 1-way analysis of variance (ANOVA) tests were used to analyze the data. Background Side effects of synthetic analgesic drugs in the clinical practice have drawn researchers’ attention on developing the herbal medicine as more appropriate analgesic agents. Objectives This study aimed to investigate the antinociceptive effect of hydroalcoholic leaf extract of Bryonia dioica (HEBD) on male rats. |
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| کلیدواژه‌های فارسی مقاله |
Pain،Plants، Medicinal،Bryonia،Formaldehyde،Rats |
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| عنوان انگلیسی |
The Antinociceptive Effects of Hydroalcoholic Extract of Bryonia dioica in Male Rats |
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| چکیده انگلیسی مقاله |
Conclusions The experimental data verified that HEBD leaves displayed remarkable antinociceptive activity. Furthermore, the nonselective opioid receptor antagonist, naloxone blocked the antinociceptive effect of the extract in all tests, suggesting that HEBD may act both at peripheral and central levels. Results Using writhing, tail-flick, and formalin tests, dramatic antinociceptive effects were observed for HEBD at the dose of 300 mg/kg with P < 0.01. The results of data analysis also revealed that there was no significant difference between indomethacin and dose of 300 mg/kg of extract in formalin test. LD50 of the plant was 4200 mg/kg. Materials and Methods In this experimental study, 42 adult male rats were divided into 7 groups: control, HEBD (80, 100, and 300 mg/kg, ip), morphine (1 mg/kg, ip), indomethacin (1 mg/kg, ip), and naloxone (1 mg/kg ip). In order to assess the analgesic effects of the extract, writhing, tail-flick, and formalin tests were used. Also, Tukey post hoc and 1-way analysis of variance (ANOVA) tests were used to analyze the data. Background Side effects of synthetic analgesic drugs in the clinical practice have drawn researchers’ attention on developing the herbal medicine as more appropriate analgesic agents. Objectives This study aimed to investigate the antinociceptive effect of hydroalcoholic leaf extract of Bryonia dioica (HEBD) on male rats. |
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| کلیدواژه‌های انگلیسی مقاله |
Pain,Plants, Medicinal,Bryonia,Formaldehyde,Rats |
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| نویسندگان مقاله |
محمد زارعی | mohammad zarei
neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran; department of physiology, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
سعید محمدی | saeed mohammadi
department of biology, faculty of basic sciences, islamic azad university, hamadan, ir iran; professor mussivand blvd, hamadan branch, islamic azad university, hamadan, ir iran. tel 98-8134494000, fax 98-8134494026
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)
نسرین ابوالحسنی | nasreen abolhassani
department of biology, faculty of basic sciences, science and research branch, islamic azad university, tehran, ir iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)
مهتاب عسگری نعمتیان | mahtab asgari nematian
department of biology, hamadan branch, payam-noor university, hamadan, ir iran
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| نشانی اینترنتی |
http://www.avicennajnpp.com/index.php?page=article&article_id=25761 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
10.17795/ajnpp-25761 |
| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
research-article |
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