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Avicenna Journal of Neuro Psycho Phyisology، جلد ۲، شماره ۲، صفحات ۰-۰
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| عنوان فارسی |
Anxiolytic Effect of Ocimum basilicum Extract in Rats Tested by Elevated Plus-Maze Task |
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| چکیده فارسی مقاله |
Conclusions Our results demonstrated that the extract of OB could induce anxiolytic effect in rats after 1 week oral administration. The effect of OB was not induced through changes in motor activity. Further investigations are necessary for pharmacological providing of OB and better understanding of its anxiolytic properties and neurobiological mechanisms. Results The results showed that after oral feeding of OB, the percentage of open arms entry and open arms time in EPM increased in the experimental groups. OB extract has no effect on the total distance covered by animals and number of closed arm entries. Materials and Methods Male Wistar rats weighing 220 - 250 g were used in the present study. Forty rats were divided into 4 groups: three OB groups (25, 50, 100 mg/kg oral administration of OB for 7 days) and a saline control group. One day after the last day of feeding, the animals’ behavior in EPM was videotaped for 10 minutes. Then, their behavior scored for formal indexes of anxiety, such as the total distance covered by animals, the percentage of entries into and the time spent in open and closed arms. Background There are reports in traditional medicine about the effectiveness of Ocimum basilicum (OB) in the treatment of anxiety. The Elevated Plus-Maze (EPM) has been predominantly used to investigate anxiety levels in rodents. Objectives The purpose of the present study was to investigate the effectiveness of extract of OB on rat behavior in the EPM test. |
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| کلیدواژه‌های فارسی مقاله |
Elevated Plus-Maze،Rat،Anxiety،Ocimum basilicum |
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| عنوان انگلیسی |
Anxiolytic Effect of Ocimum basilicum Extract in Rats Tested by Elevated Plus-Maze Task |
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| چکیده انگلیسی مقاله |
Conclusions Our results demonstrated that the extract of OB could induce anxiolytic effect in rats after 1 week oral administration. The effect of OB was not induced through changes in motor activity. Further investigations are necessary for pharmacological providing of OB and better understanding of its anxiolytic properties and neurobiological mechanisms. Results The results showed that after oral feeding of OB, the percentage of open arms entry and open arms time in EPM increased in the experimental groups. OB extract has no effect on the total distance covered by animals and number of closed arm entries. Materials and Methods Male Wistar rats weighing 220 - 250 g were used in the present study. Forty rats were divided into 4 groups: three OB groups (25, 50, 100 mg/kg oral administration of OB for 7 days) and a saline control group. One day after the last day of feeding, the animals’ behavior in EPM was videotaped for 10 minutes. Then, their behavior scored for formal indexes of anxiety, such as the total distance covered by animals, the percentage of entries into and the time spent in open and closed arms. Background There are reports in traditional medicine about the effectiveness of Ocimum basilicum (OB) in the treatment of anxiety. The Elevated Plus-Maze (EPM) has been predominantly used to investigate anxiety levels in rodents. Objectives The purpose of the present study was to investigate the effectiveness of extract of OB on rat behavior in the EPM test. |
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| کلیدواژه‌های انگلیسی مقاله |
Elevated Plus-Maze,Rat,Anxiety,Ocimum basilicum |
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| نویسندگان مقاله |
زهرا نعمتی | zahra nemati
neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
سمانه اویسی | samaneh oveisi
neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
علیرضا کمکی | alireza komaki
neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran; department of physiology, school of medicine, hamadan university of medical sciences, hamadan, ir iran; department of physiology, school of medicine, hamadan university of medical sciences, p. o. box 65178 518, hamadan, ir iran. tel 98-8138380267, fax 98-8138380131
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
سیامک شهیدی | siamak shahidi
neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
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| نشانی اینترنتی |
http://www.avicennajnpp.com/index.php?page=article&article_id=31136 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
10.17795/ajnpp-31136 |
| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
research-article |
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