Avicenna Journal of Neuro Psycho Phyisology، جلد ۲، شماره ۳، صفحات ۰-۰
عنوان فارسی Effects of Acute Administration of Urtica dioica on the Novel Object-Recognition Task in Mice
چکیده فارسی مقاله Conclusions Acute administration of U. dioica impairs the object-recognition task if it is used only before the training session. This may be due to its modulation on the acquisition processing of object-recognition. U. dioica has no significant effects on the consolidation or retrieval processing stages of the NOR task. These results emphasize the unfavorable effect on cognitive function of pre-training with acute supplementation of U. dioica. Results The results showed that there was a preference for the novel object compared to the familiar one in each of the experimental groups. The object-recognition discrimination index in the group of mice that received U. dioica before training was significantly less than in the other experimental groups. There was no significant difference in the discrimination index between the other groups. U. dioica did not decrease the time spent exploring familiar and unfamiliar objects, or the total time spent exploring both objects. Materials and Methods First, U. dioica aqueous extract was prepared, then adult male mice were randomly divided into four experimental groups. During the training session, the mice were placed in a box and given 5 minutes to explore two identical objects. The next day, they were again placed in the box and allowed to explore one familiar and one novel object. They received intraperitoneal injections of saline or U. dioica aqueous extract (100 mg/kg) before or immediately after the training session or before the test session of the NOR task. Background Urtica dioica (nettle) has a variety of uses in traditional medicine for the treatment of certain urogenital problems, gastrointestinal disorders, and diabetes. Objectives Recent studies have implicated the effect of U. dioica on brain functions such as pain and memory. However, there is no direct evidence of the acute effects of this plant on cognition. The aim of the present study was to evaluate the effect of U. dioica aqueous extract on the novel object-recognition task (NOR) in mice.
کلیدواژه‌های فارسی مقاله Mice،Novel Object Recognition،Urtica dioica
عنوان انگلیسی Effects of Acute Administration of Urtica dioica on the Novel Object-Recognition Task in Mice
چکیده انگلیسی مقاله Conclusions Acute administration of U. dioica impairs the object-recognition task if it is used only before the training session. This may be due to its modulation on the acquisition processing of object-recognition. U. dioica has no significant effects on the consolidation or retrieval processing stages of the NOR task. These results emphasize the unfavorable effect on cognitive function of pre-training with acute supplementation of U. dioica. Results The results showed that there was a preference for the novel object compared to the familiar one in each of the experimental groups. The object-recognition discrimination index in the group of mice that received U. dioica before training was significantly less than in the other experimental groups. There was no significant difference in the discrimination index between the other groups. U. dioica did not decrease the time spent exploring familiar and unfamiliar objects, or the total time spent exploring both objects. Materials and Methods First, U. dioica aqueous extract was prepared, then adult male mice were randomly divided into four experimental groups. During the training session, the mice were placed in a box and given 5 minutes to explore two identical objects. The next day, they were again placed in the box and allowed to explore one familiar and one novel object. They received intraperitoneal injections of saline or U. dioica aqueous extract (100 mg/kg) before or immediately after the training session or before the test session of the NOR task. Background Urtica dioica (nettle) has a variety of uses in traditional medicine for the treatment of certain urogenital problems, gastrointestinal disorders, and diabetes. Objectives Recent studies have implicated the effect of U. dioica on brain functions such as pain and memory. However, there is no direct evidence of the acute effects of this plant on cognition. The aim of the present study was to evaluate the effect of U. dioica aqueous extract on the novel object-recognition task (NOR) in mice.
کلیدواژه‌های انگلیسی مقاله Mice,Novel Object Recognition,Urtica dioica
نویسندگان مقاله نسرین هاشمی فیروزی | nasrin hashemi firouzi
neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

مرجان اخوان | marjan akhavan
neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

علیرضا کمکی | alireza komaki
neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

سیامک شهیدی | siamak shahidi
neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran; neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran. tel 98-8138380462, fax 98-8138380208

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

نشانی اینترنتی http://www.avicennajnpp.com/index.php?page=article&article_id=34150
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کد مقاله (doi) 10.17795/ajnpp-34150
زبان مقاله منتشر شده fa
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نوع مقاله منتشر شده research-article
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