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Avicenna Journal of Neuro Psycho Phyisology، جلد ۲، شماره ۳، صفحات ۰-۰
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| عنوان فارسی |
The Effect of Different Training Modes on Serum Apelin and Pain Threshold in Morphine-Dependent Rats |
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| چکیده فارسی مقاله |
Conclusions The results showed that endurance training reduced pain by increasing apelin in morphine-dependent rats. Therefore, it is suggested that this type of training be considered for the morphine-dependent patients for pain relief. Objectives Therefore, the aim of this study was to evaluate apelin and pain threshold changes in healthy and morphine-dependent rats in response to two exercise paradigms. Materials and Methods In this study, 30 healthy and 30 morphine-dependent rats were used. Morphine-dependent and healthy rats were divided into six groups: 1, a control (healthy) group; 2, a healthy endurance group; 3, a healthy strength-training group; 4, an addicted control group; 5, an addicted endurance group; 6, an addicted strength-training group. Then, the training groups performed aerobic and strength training for eight weeks. After the training program, the tail flick and formalin tests were used to assess pain. Apelin was also measured by ELISA. Results Regardless of the type of exercise, exercise significantly increased the apelin serum levels in healthy rats. The apelin levels significantly increased in the morphine-dependent rats compared with the healthy control group. Endurance, unlike strength training, significantly increased apelin in the serum compared to the addicted control group. The training led to pain relief in the morphine-dependent rats and returned it to the healthy control group level. The Pearson correlation showed a reverse significant correlation between the serum apelin level and the tail flick test in the morphine-dependent rats. Background Apelin has recently been identified as an analgesic agent and a novel neuropeptide. On the other hand, it has been shown that exercise can lead to reduced pain in morphine-dependent patients. |
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| کلیدواژه‌های فارسی مقاله |
Exercise Training،Analgesics،Pain Threshold،Morphine،Apelin |
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| عنوان انگلیسی |
The Effect of Different Training Modes on Serum Apelin and Pain Threshold in Morphine-Dependent Rats |
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| چکیده انگلیسی مقاله |
Conclusions The results showed that endurance training reduced pain by increasing apelin in morphine-dependent rats. Therefore, it is suggested that this type of training be considered for the morphine-dependent patients for pain relief. Objectives Therefore, the aim of this study was to evaluate apelin and pain threshold changes in healthy and morphine-dependent rats in response to two exercise paradigms. Materials and Methods In this study, 30 healthy and 30 morphine-dependent rats were used. Morphine-dependent and healthy rats were divided into six groups: 1, a control (healthy) group; 2, a healthy endurance group; 3, a healthy strength-training group; 4, an addicted control group; 5, an addicted endurance group; 6, an addicted strength-training group. Then, the training groups performed aerobic and strength training for eight weeks. After the training program, the tail flick and formalin tests were used to assess pain. Apelin was also measured by ELISA. Results Regardless of the type of exercise, exercise significantly increased the apelin serum levels in healthy rats. The apelin levels significantly increased in the morphine-dependent rats compared with the healthy control group. Endurance, unlike strength training, significantly increased apelin in the serum compared to the addicted control group. The training led to pain relief in the morphine-dependent rats and returned it to the healthy control group level. The Pearson correlation showed a reverse significant correlation between the serum apelin level and the tail flick test in the morphine-dependent rats. Background Apelin has recently been identified as an analgesic agent and a novel neuropeptide. On the other hand, it has been shown that exercise can lead to reduced pain in morphine-dependent patients. |
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| کلیدواژه‌های انگلیسی مقاله |
Exercise Training,Analgesics,Pain Threshold,Morphine,Apelin |
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| نویسندگان مقاله |
ابراهیم زرین کلام | ebrahim zarrinkalam
department of exercise physiology, faculty of physical education and sport science, bu ali sina university, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه بوعلی سینا (Bu ali sina university)
علی حیدریان پور | ali heidarianpour
department of exercise physiology, faculty of physical education and sport science, bu ali sina university, hamadan, ir iran; department of exercise physiology, faculty of physical education and sport science, bu ali sina university, hamadan, ir iran. tel 98-9188187984
سازمان اصلی تایید شده: دانشگاه بوعلی سینا (Bu ali sina university)
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| نشانی اینترنتی |
http://www.avicennajnpp.com/index.php?page=article&article_id=34440 |
| فایل مقاله |
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| کد مقاله (doi) |
10.17795/ajnpp-34440 |
| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
research-article |
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