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Avicenna Journal of Neuro Psycho Phyisology، جلد ۱، شماره ۲، صفحات ۰-۰
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| عنوان فارسی |
Acute and Chronic Effects of ۳-۴, Methylenedioxymethamphetamine on Pyramidal Cells of Hippocampus |
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| چکیده فارسی مقاله |
Background Ecstasy or 3-4, methylenedioxymethamphetamine (MDMA), as an amphetamine derivate, could lead to learning and memory impairment. Objectives As the hippocampus is responsible for learning and memory, herein we evaluated acute and chronic effects of MDMA on the structure of the hippocampus. Materials and Methods Male Wistar rats (200-250 g) received single or multiple injections of MDMA (10 mg/kg, IP). At the end of the study, rats were killed and their brains were removed. Hippocampus sections were prepared to study the structure of hippocampus CA1. Data was analyzed using SPSS 16 software and one-way analysis of variance test. Results Our findings showed that cell density decreased in MDMA-treated groups in comparison to the intact group. Administration of multiple doses of MDMA significantly decreased the cell number when compared with intact (P < 0.001) and acute (P < 0.01) groups. Conclusions These data suggest that MDMA treatment caused cell death in CA1, which was more extensive in the chronic treatment group. |
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| کلیدواژه‌های فارسی مقاله |
Methylenedioxymethamphetamine،Hippocampus،Cell Death |
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| عنوان انگلیسی |
Acute and Chronic Effects of 3-4, Methylenedioxymethamphetamine on Pyramidal Cells of Hippocampus |
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| چکیده انگلیسی مقاله |
Background Ecstasy or 3-4, methylenedioxymethamphetamine (MDMA), as an amphetamine derivate, could lead to learning and memory impairment. Objectives As the hippocampus is responsible for learning and memory, herein we evaluated acute and chronic effects of MDMA on the structure of the hippocampus. Materials and Methods Male Wistar rats (200-250 g) received single or multiple injections of MDMA (10 mg/kg, IP). At the end of the study, rats were killed and their brains were removed. Hippocampus sections were prepared to study the structure of hippocampus CA1. Data was analyzed using SPSS 16 software and one-way analysis of variance test. Results Our findings showed that cell density decreased in MDMA-treated groups in comparison to the intact group. Administration of multiple doses of MDMA significantly decreased the cell number when compared with intact (P < 0.001) and acute (P < 0.01) groups. Conclusions These data suggest that MDMA treatment caused cell death in CA1, which was more extensive in the chronic treatment group. |
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| کلیدواژه‌های انگلیسی مقاله |
Methylenedioxymethamphetamine,Hippocampus,Cell Death |
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| نویسندگان مقاله |
محمد بختیار حسام شریعتی | mohamad bakhtiar hesam shariati
research center for behavioral disorders and substance abuse, hamadan university of medical sciences, hamadan, ir iran; department of anatomy, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
فاطمه میرزایی | fatemeh mirzaei
department of anatomy, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
سارا سلیمانی اصل | sara soleimani asl
research center for behavioral disorders and substance abuse, hamadan university of medical sciences, hamadan, ir iran; department of anatomy, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
لیلا موسوی | leila mosavi
department of pathology, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
مریم سهرابی | maryam sohrabi
department of anatomy, hamadan university of medical sciences, hamadan, ir iran; department of anatomy, school of medicine, hamadan university of medical sciences, hamadan, ir iran. tel fax 98-8118380208
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
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| نشانی اینترنتی |
http://www.avicennajnpp.com/index.php?page=article&article_id=21812 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
10.17795/ajnpp-21812 |
| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
research-article |
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