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Avicenna Journal of Neuro Psycho Phyisology، جلد ۶، شماره ۱، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Chronic administration of donepezil on inhibitory and spatial learning and memory in male rats |
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| چکیده انگلیسی مقاله |
Cholinergic dysfunction involves in age related cognitive deficits and Alzheimer disease. Donepezil is a reversible acetylcholinesterase (AChE) inhibitor. The present experiments examined the ability of chronic supplementation with donepezil on the cognition in the healthy young rats. Twenty young male Wistar rats (140-160 g) were divided into control and donepezil groups. The rats received oral administration of saline or 0.3 mg/kg of donepezil for 30consecutive days. Then they were trained and tested in the inhibitory avoidance (IA) and eight radial arm maze (RM) tasks. The results indicate that there was neither significant difference in the number of trials to acquisition in the IA nor number of baited food arms in RM tasks between experimental groups. In the IA retrieval test, the time spent in the dark compartment in the donepezil treated group was significantly less than saline treated group. Also, in the RM retrieval test, the number of total memory and working memory errors of donepezil treated rats was significantly less than saline treated one. It can be concluded that chronic administration of donepezil (0.3 mg/kg) had no significant effects on the learning process but it can improve memory performance in normal rat. |
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| کلیدواژه‌های انگلیسی مقاله |
Donepezil, learning, memory, Rat |
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| نویسندگان مقاله |
| Nasrin Hashemi-Firouzi
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
| Ali Ghaleiha
Research Center for Behavioral Disorders and Substance Abuse, Hamadan University of Medial Sciences, Hamadan, Iran
| Alireza Komaki
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
| Siamak Shahidi
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
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| نشانی اینترنتی |
http://ajnpp.umsha.ac.ir/browse.php?a_code=A-10-171-1&slc_lang=en&sid=1 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/363/article-363-1907613.doc |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Learning and Memory, Dementia, Alzheimer |
| نوع مقاله منتشر شده |
پژوهشی |
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