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Journal of Research in Health Sciences، جلد ۲۱، شماره ۲، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Modeling Time to Death of Patients with Multidrug-Resistant Tuberculosis at Saint Peter’s Specialized Hospital |
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| چکیده انگلیسی مقاله |
Background: Currently, the worldwide prevalence and incidence of multidrug-resistant tuberculosis (MDR-TB) is drastically increasing. The main objective of this study was modeling the time-to-death of patients with MDR-TB at St. Peter’s Specialized Hospital, Addis Ababa, Ethiopia, by using various parametric shared frailty models. Study Design: A retrospective study design was used. Methods: The study population was TB patients with MDR at St. Peter’s Specialized Hospital from January 2016 through December 2019. Exponential, Weibull, and log-normal were used as baseline hazard functions with the gamma and inverse Gaussian frailty distributions. All the models were compared based on Akaike’s Information Criteria. Results: The overall median time to death was 11 months and 123 (33.5%) patients died. Patients who lived in rural areas had shorter survival time than those who lived in urban areas with an accelerated factor of 0.135 ( P =0.002). Patients with a history of anti-TB drug consumption had a short survival time than those without such a history with an accelerated factor of 0.02 ( P =0.001). The variability (heterogeneity) of time to death of patients in the region for the selected model (Weibull-inverse Gaussian shared frailty model) was =0.144 ( P =0.027). Conclusion: The MDR-TB patients with weight gain, khat and alcohol consumption, clinical complication of pneumothorax and pneumonia, extrapulmonary TB, and history of anti-TB drug consumption as well as those who lived in rural areas had a shorter survival time, compared to others. There was a significant heterogeneity effect in the St. Peter’s Specialized Hospital. The best model for predicting the time to death of MDR-TB patients was Weibull-inverse Gaussian shared frailty model. |
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| کلیدواژه‌های انگلیسی مقاله |
Hospital,Multidrug-Resistance Tuberculosis,Retrospective,Shared frailty,Time-to-Death |
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| نویسندگان مقاله |
| Teramaj Wongel Wotale
| Abiyot Negash Terefe
| Jaleta Abdisa Fufa
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| نشانی اینترنتی |
http://jrhs.umsha.ac.ir/index.php/JRHS/article/view/6600 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
10.34172/jrhs.v0i0.6600 |
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Articles |
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