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Avicenna Journal of Neuro Psycho Phyisology، جلد ۸، شماره ۴، صفحات ۱۷۸-۱۸۵
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Protective effect of swimming and genistein on the expression of microRNA 132, insulin growth factor 1, and brain-derived neurotrophic factor genes, as well as spatial memory, in the hippocampus of diabetic ovariectomized rats |
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| چکیده انگلیسی مقاله |
Background and Objective: The present study aimed to assess the effects of the combined use of exercise and genistein on the hippocampal expression of microRNA-132, IGF-1, and BDNF in type 2 diabetic ovariectomized rats. Materials and Methods: Wistar female rats in the weight range of 180-220 gr (n=10) were assigned to six groups: sham, ovariectomy, ovariectomized diabetic, ovariectomized diabetic treated with genistein for eight weeks, diabetic ovariectomized treated with swimming for eight weeks, and a group that was treated with both genistein and swimming for eight weeks. The effect of those treatments was assessed by the determination of microRNA-132, insulin growth factor 1 (IGF-1), and brain-derived neurotrophic factor (BDNF) expression levels within the hippocampus. These genes were evaluated by real-time-polymerase chain reaction (RT-PCR) and spatial memory was assessed by the Morris water maze. Results: Ovariectomy demonstrated a decrease in the expression of microRNA-132, IGF-1, and BDNF in the hippocampus, as well as spatial memory, in diabetic ovariectomized rats, which showed a greater reduction in the expression of those genes in rats (P< 0.05). Nevertheless, genistein administration, swimming training, and a combination of them significantly up-regulated microRNA-132, BDNF, and IGF-1 expression, as well as spatial memory (P< 0.05). Conclusions: As evidenced by the obtained results, the combined use of genistein and swimming could prevent estrogen deficiency effects in the hippocampus of ovariectomized diabetic rats |
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| کلیدواژه‌های انگلیسی مقاله |
Diabetes, Genistein, Ovariectomy, Spatial Memory, Swimming |
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| نویسندگان مقاله |
| Shirin Babri
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
| Parisa Habibi
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
| Fatemeh Nouri
Department of Pharmaceutical Biotechnology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
| Mehdi Khazaei
Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran
| Sepehr Nayebi Rad
Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
| Gonja Javani
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
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| نشانی اینترنتی |
http://ajnpp.umsha.ac.ir/browse.php?a_code=A-10-265-1&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Physiology |
| نوع مقاله منتشر شده |
پژوهشی |
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