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Avicenna Journal of Neuro Psycho Phyisology، جلد ۸، شماره ۲، صفحات ۶۴-۷۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Possible Involvement of Serotonergic Mechanism(s) in the Antinociceptive Effects of kaempferol |
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| چکیده انگلیسی مقاله |
Background and Objectives: A flavonoid kaempferol (KM) exerts an anti-inflammatory effect and is reportedly capable of preventing metabolic diseases. Nonetheless, a limited number of studies have been carried out on the antinociceptive effects of kaempferol. Objectives: The present study aimed to investigate the involvement of serotonin receptors in the antinociceptive-like activity of KM in male Wistar rats using the tail-flick test. Materials and Methods: The compounds (i.e., KM, morphine, and diclofenac) were intracerebroventricularly administered to rats for the examination of central effects on the thermal pain using the tail-flick test. For the evaluation of the involvement of serotonin receptors in the possible antinociceptive effects of kaempferol, several antagonists (i.e., tropisetron, ketanserin, GR113808, WAY 100635, and penbutolol) were used. Additionally, locomotor activity and motor responses were investigated by the rotarod test after KM treatment. Results: The intracerebroventricular microinjections of KM showed antinociceptive effects using the tail-flick test. The pretreatment with tropisetron as a 5-HT3 receptor antagonist at 1 and 10 mg completely reversed the KM-related antinociception. Furthermore, ketanserin (5-HT2A receptor antagonist) and GR113808 (5-HT4 receptor antagonist) both at 10 mg reduced KM-related antinociception; however, 5-HT1A receptor antagonist WAY 100635 and 5-HT1B antagonist penbutolol did not decrease KM-related antinociception. All KM doses were not observed with a significant effect on locomotor activity or motor reactions. Conclusion: The results of the current study suggested that serotonergic receptors (i.e., 5-HT2A, 5-HT3, and 5-HT4) are effective in the KM antinociceptive activity in male rats. |
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| کلیدواژه‌های انگلیسی مقاله |
Central nervous system, Kaempferol, Pain, Serotonin receptors |
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| نویسندگان مقاله |
| Sajjad Jabbari
Department of Biology, Faculty of Life Sciences, Islamic Azad University, Tehran North Branch, Tehran, Iran.
| Maryam Bananej
Department of Biology, Faculty of Life Sciences, Islamic Azad University, Tehran North Branch, Tehran, Iran
| Mohammad Zarei
Department of Physology, Scihool of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
| Alireza Komaki
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
| Ramin Hajikhani
Department of Biology, Faculty of Life Sciences, Islamic Azad University, Tehran North Branch, Tehran, Iran
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| نشانی اینترنتی |
http://ajnpp.umsha.ac.ir/browse.php?a_code=A-10-334-1&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
Cognition |
| نوع مقاله منتشر شده |
پژوهشی |
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