|
|
Avicenna Journal of Clinical Microbiology and Infection، جلد ۳، شماره ۲، صفحات ۰-۰
|
|
|
| عنوان فارسی |
The Pro۱۱۵Gln Missense Mutation of Peroxisome Proliferator Activated Receptor γ (PPARγ) Gene in Diabetes in the Pakistani Population |
|
| چکیده فارسی مقاله |
Conclusions In conclusion, as this mutation is present in a highly conserved region and any change in this region would adversely affect the protein structure and function, so the prevalence of this mutation is very low. Background Diabetes is an alarmingly increasing public health concern. According to a World Health Organization (WHO) report, diabetes is highly prevalent in almost all regions of Pakistan, with an overall prevalence of 22.04% in urban and 17.15% in rural areas. In addition to lifestyle factors, genetics plays an important part in the progression to diabetes, of which peroxisome proliferator activated receptors (PPARs), a super-family of transcriptional regulators, are considered to be very critical. Objectives The aim of the current study was to investigate the prevalence of a missense mutation Pro115Gln in the PPARγ; gene in Pakistan and search for its effects on certain serum biochemical parameters. Materials and Methods A total of 1015 subjects (490 diabetics and 525 healthy controls) were genotyped by PCR-RFLP and serum profiling was performed. Results We could not detect the mutation in the study subjects, but the anthropometric and biochemical parameters were significantly different between the cases and controls. |
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
The Pro115Gln Missense Mutation of Peroxisome Proliferator Activated Receptor γ (PPARγ) Gene in Diabetes in the Pakistani Population |
|
| چکیده انگلیسی مقاله |
Conclusions In conclusion, as this mutation is present in a highly conserved region and any change in this region would adversely affect the protein structure and function, so the prevalence of this mutation is very low. Background Diabetes is an alarmingly increasing public health concern. According to a World Health Organization (WHO) report, diabetes is highly prevalent in almost all regions of Pakistan, with an overall prevalence of 22.04% in urban and 17.15% in rural areas. In addition to lifestyle factors, genetics plays an important part in the progression to diabetes, of which peroxisome proliferator activated receptors (PPARs), a super-family of transcriptional regulators, are considered to be very critical. Objectives The aim of the current study was to investigate the prevalence of a missense mutation Pro115Gln in the PPARγ; gene in Pakistan and search for its effects on certain serum biochemical parameters. Materials and Methods A total of 1015 subjects (490 diabetics and 525 healthy controls) were genotyped by PCR-RFLP and serum profiling was performed. Results We could not detect the mutation in the study subjects, but the anthropometric and biochemical parameters were significantly different between the cases and controls. |
|
| کلیدواژه‌های انگلیسی مقاله |
|
|
| نویسندگان مقاله |
sarwar sumbal | sarwar sumbal
department of microbiology and molecular genetics, university of the punjab, lahore, pakistan
shabana | shabana
department of microbiology and molecular genetics, university of the punjab, lahore, pakistan; department of microbiology and molecular genetics, university of the punjab, lahore, pakistan. tel 92-3324327547, fax 92-4235952855
|
|
| نشانی اینترنتی |
http://www.ajcmicrob.com/index.php?page=article&article_id=35148 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/1795/article-1795-276853.pdf |
| کد مقاله (doi) |
10.17795/ajcmi-35148 |
| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
|
| نوع مقاله منتشر شده |
research-article |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|