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Avicenna Journal of Clinical Microbiology and Infection، جلد ۳، شماره ۲، صفحات ۰-۰
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| عنوان فارسی |
Prevalence of A۲۱۴۳G and A۲۱۴۴G Point Mutations Responsible for Clarithromycin Resistance among Helicobacter pylori Strains in Bushehr, Iran |
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| چکیده فارسی مقاله |
Results Of the 135 H. pylori-positive specimens, two harbored strains with the A2143G mutation and nine contained strains with the A2144G mutation. Thus, the prevalences of the A2143G and A2144G point mutations were 1.5% and 6.7%, respectively. The A2143C point mutation was not found. Conclusions The prevalences of the point mutations A2143G and A2144G were low in our geographic area. Based on the findings of this study, clarithromycin still seems to be a useful antibiotic for initial treatment regimens in Bushehr, Iran. Patients and Methods Gastric biopsy specimens were obtained from patients with upper gastrointestinal symptoms during endoscopy. Fluorescent in situ hybridization (FISH) using oligonucleotide probes was applied to detect the point mutations responsible for clarithromycin resistance in H. pylori. Background Resistance to clarithromycin in Helicobacter pylori has become one of the most important reasons for failure of antibiotic eradication therapies. This resistance is predominantly caused by point mutations in the peptidyl transferase region of 23S rRNA. Objectives The aim of this study was to determine the prevalence of the A2143G, A2144G, and A2143C point mutations among H. pylori strains from gastric biopsy specimens in Bushehr, in the southwest of Iran. |
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| کلیدواژه‌های فارسی مقاله |
Clarithromycin Resistance،Point Mutation،Helicobacter pylori |
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| عنوان انگلیسی |
Prevalence of A2143G and A2144G Point Mutations Responsible for Clarithromycin Resistance among Helicobacter pylori Strains in Bushehr, Iran |
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| چکیده انگلیسی مقاله |
Results Of the 135 H. pylori-positive specimens, two harbored strains with the A2143G mutation and nine contained strains with the A2144G mutation. Thus, the prevalences of the A2143G and A2144G point mutations were 1.5% and 6.7%, respectively. The A2143C point mutation was not found. Conclusions The prevalences of the point mutations A2143G and A2144G were low in our geographic area. Based on the findings of this study, clarithromycin still seems to be a useful antibiotic for initial treatment regimens in Bushehr, Iran. Patients and Methods Gastric biopsy specimens were obtained from patients with upper gastrointestinal symptoms during endoscopy. Fluorescent in situ hybridization (FISH) using oligonucleotide probes was applied to detect the point mutations responsible for clarithromycin resistance in H. pylori. Background Resistance to clarithromycin in Helicobacter pylori has become one of the most important reasons for failure of antibiotic eradication therapies. This resistance is predominantly caused by point mutations in the peptidyl transferase region of 23S rRNA. Objectives The aim of this study was to determine the prevalence of the A2143G, A2144G, and A2143C point mutations among H. pylori strains from gastric biopsy specimens in Bushehr, in the southwest of Iran. |
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| کلیدواژه‌های انگلیسی مقاله |
Clarithromycin Resistance,Point Mutation,Helicobacter pylori |
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| نویسندگان مقاله |
سعید تاج بخش | saeed tajbakhsh
department of microbiology and parasitology, faculty of medicine, bushehr university of medical sciences, bushehr, ir iran; the persian gulf tropical medicine research center, bushehr university of medical sciences, bushehr, ir iran; department of microbiology and parasitology, faculty of medicine, bushehr university of medical sciences, bushehr, ir iran. tel 98-9177746164, fax 98-7733320657
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بوشهر (Bushehr university of medical sciences)
جمال فلاحی | jamal falahi
department of microbiology and parasitology, faculty of medicine, bushehr university of medical sciences, bushehr, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بوشهر (Bushehr university of medical sciences)
نیلوفر معتمد | niloofar motamed
department of community medicine, faculty of medicine, bushehr university of medical sciences, bushehr, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بوشهر (Bushehr university of medical sciences)
سید مسعود طبیب | seyed masoud tabib
department of internal medicine, faculty of medicine, bushehr university of medical sciences, bushehr, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بوشهر (Bushehr university of medical sciences)
عباس بهادر | abbas bahador
department of microbiology, school of medicine, tehran university of medical sciences, tehran, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
سمیه غریبی | somayyeh gharibi
the persian gulf tropical medicine research center, bushehr university of medical sciences, bushehr, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بوشهر (Bushehr university of medical sciences)
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| نشانی اینترنتی |
http://www.ajcmicrob.com/index.php?page=article&article_id=36521 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/1795/article-1795-276856.pdf |
| کد مقاله (doi) |
10.17795/ajcmi-36521 |
| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
research-article |
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