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Avicenna Journal of Clinical Microbiology and Infection، جلد ۲، شماره ۱، صفحات ۰-۰
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| عنوان فارسی |
The Antibacterial Effect of American Cockroach Hemolymph on the Nosocomial Pathogenic Bacteria |
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| چکیده فارسی مقاله |
Conclusions The study results showed that stimulation of the American cockroach’s immunity system lead to production of antibacterial proteins and peptides which had inhibitory effect on the bacteria, depending on the bacterial strains and their sensitivity. Likely this feature of insects can be used as therapeutic strategies to produce natural antimicrobial compounds against the pathogenic bacteria. Materials and Methods To stimulate adult cockroaches' immune system, Escherichia coli cells were injected. The antimicrobial effect of the extracted induced and non-induced hemolymph was assayed on many susceptible and resistant pathogenic bacteria. Results The comparison of antimicrobial effects of the induced and non-induced hemolymph strains showed that about 43% of bacteria were sensitive to induced hemolymph (P < 0.001), whereas non-induced hemolymph showed no inhibitory effect on the bacteria. Also, evaluation of induced hemolymph effect on the types of strains showed that induced hemolymph affected about 75% of the susceptible bacterial strains (P < 0.001); whereas, it did not affect the resistant strains. Among the tested bacteria, ceftazidime-sensitive E. coli and methicillin-sensitive Staphylococcus aureus showed sensitivity to the induced hemolymph (P < 0.001). Background Insects are able to recognize many pathogenic microorganisms and defend against them due to their long evolutionary history. Due to the development of resistance to synthetic antibiotics, researchers are trying to apply insect immune-derived products. Objectives The current study aimed to investigate the antibacterial effect of the American cockroach (Periplaneta americana) hemolymph on susceptible and resistant strains of nosocomial bacteria. |
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| کلیدواژه‌های فارسی مقاله |
Hemolymph،Periplaneta americana،Anti-Bacterial Agents |
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| عنوان انگلیسی |
The Antibacterial Effect of American Cockroach Hemolymph on the Nosocomial Pathogenic Bacteria |
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| چکیده انگلیسی مقاله |
Conclusions The study results showed that stimulation of the American cockroach’s immunity system lead to production of antibacterial proteins and peptides which had inhibitory effect on the bacteria, depending on the bacterial strains and their sensitivity. Likely this feature of insects can be used as therapeutic strategies to produce natural antimicrobial compounds against the pathogenic bacteria. Materials and Methods To stimulate adult cockroaches' immune system, Escherichia coli cells were injected. The antimicrobial effect of the extracted induced and non-induced hemolymph was assayed on many susceptible and resistant pathogenic bacteria. Results The comparison of antimicrobial effects of the induced and non-induced hemolymph strains showed that about 43% of bacteria were sensitive to induced hemolymph (P < 0.001), whereas non-induced hemolymph showed no inhibitory effect on the bacteria. Also, evaluation of induced hemolymph effect on the types of strains showed that induced hemolymph affected about 75% of the susceptible bacterial strains (P < 0.001); whereas, it did not affect the resistant strains. Among the tested bacteria, ceftazidime-sensitive E. coli and methicillin-sensitive Staphylococcus aureus showed sensitivity to the induced hemolymph (P < 0.001). Background Insects are able to recognize many pathogenic microorganisms and defend against them due to their long evolutionary history. Due to the development of resistance to synthetic antibiotics, researchers are trying to apply insect immune-derived products. Objectives The current study aimed to investigate the antibacterial effect of the American cockroach (Periplaneta americana) hemolymph on susceptible and resistant strains of nosocomial bacteria. |
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| کلیدواژه‌های انگلیسی مقاله |
Hemolymph,Periplaneta americana,Anti-Bacterial Agents |
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| نویسندگان مقاله |
میلاد لطیفی | milad latifi
department of medical entomology, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
محمد یوسف علیخانی | mohammad yousef alikhani
department of medical microbiology, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
عارف صالح زاده | aref salehzadeh
department of medical entomology, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
منصور نظری | mansour nazari
department of medical entomology, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
علیرضا بندانی | ali reza bandani
department of plant protection, tehran university of medical sciences, tehran, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
امیرحسین ظهیرنیا | amir hossein zahirnia
department of medical entomology, hamadan university of medical sciences, hamadan, ir iran; department of medical entomology, hamadan university of medical sciences, hamadan, ir iran. tel 98-9188115375
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
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| نشانی اینترنتی |
http://www.ajcmicrob.com/index.php?page=article&article_id=23017 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/1795/article-1795-276874.pdf |
| کد مقاله (doi) |
10.17795/ajcmi-23017 |
| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
research-article |
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