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Avicenna Journal of Clinical Microbiology and Infection، جلد ۲، شماره ۴، صفحات ۰-۰
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| عنوان فارسی |
High Prevalence of Iron Acquisition Genes Among Acinetobacter baumannii Strains Isolated From Patients With Urinary Tract Infections in Southeast of Iran |
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| چکیده فارسی مقاله |
Conclusions This is the first report on the prevalence of iron acquisition genes among A. baumannii isolates collected from patients with urinary tract infections. The high prevalence of iron acquisition genes in A. baumannii isolates suggests that these virulence factors play an important role in the development of urinary tract infections. Results A high prevalence of genes encoding iron acquisition systems were observed in A. baumannii isolates. The frequency of tonB, barA, feoB, entA, A1S_2563, and hemO genes were 85, 97, 99, 98, 99, and 95%, respectively. Based on the distribution of the various iron acquisition genes, all the studied isolates exhibited seven gene profile patterns. Objectives The aim of this study was to determine the frequency of iron acquisition genes among A. baumannii isolates, collected from patients with urinary tract infections, for the first time in Iran. Patients and Methods A total of 100 A. baumannii isolates were collected from patients with urinary tract infections in Zabol, southeast of Iran. All isolates were evaluated to determine the prevalence of iron acquisition genes, including tonB (TonB-dependent receptor), barA (acinetobactin ABC transporter), feoB (ferrous iron transport protein B), entA (acinetobactin siderophore precursor), A1S_2563 (siderophore-interacting protein), and hemO (heme oxygenase) using the multiplex polymerase chain reaction (PCR) method. Background Acinetobacter baumannii is the most clinically prominent species of the Acinetobacter genus and is commonly found in hospital environments. In mammals, the iron element is virtually unavailable to invading bacteria, being mainly incorporated into iron transport and storage proteins. Therefore, iron acquisition systems are important factors for the pathogenicity of A. baumannii strains. |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
High Prevalence of Iron Acquisition Genes Among Acinetobacter baumannii Strains Isolated From Patients With Urinary Tract Infections in Southeast of Iran |
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| چکیده انگلیسی مقاله |
Conclusions This is the first report on the prevalence of iron acquisition genes among A. baumannii isolates collected from patients with urinary tract infections. The high prevalence of iron acquisition genes in A. baumannii isolates suggests that these virulence factors play an important role in the development of urinary tract infections. Results A high prevalence of genes encoding iron acquisition systems were observed in A. baumannii isolates. The frequency of tonB, barA, feoB, entA, A1S_2563, and hemO genes were 85, 97, 99, 98, 99, and 95%, respectively. Based on the distribution of the various iron acquisition genes, all the studied isolates exhibited seven gene profile patterns. Objectives The aim of this study was to determine the frequency of iron acquisition genes among A. baumannii isolates, collected from patients with urinary tract infections, for the first time in Iran. Patients and Methods A total of 100 A. baumannii isolates were collected from patients with urinary tract infections in Zabol, southeast of Iran. All isolates were evaluated to determine the prevalence of iron acquisition genes, including tonB (TonB-dependent receptor), barA (acinetobactin ABC transporter), feoB (ferrous iron transport protein B), entA (acinetobactin siderophore precursor), A1S_2563 (siderophore-interacting protein), and hemO (heme oxygenase) using the multiplex polymerase chain reaction (PCR) method. Background Acinetobacter baumannii is the most clinically prominent species of the Acinetobacter genus and is commonly found in hospital environments. In mammals, the iron element is virtually unavailable to invading bacteria, being mainly incorporated into iron transport and storage proteins. Therefore, iron acquisition systems are important factors for the pathogenicity of A. baumannii strains. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
حسین علی عبدی | hossein ali abdi
department of biology, faculty of science, university of zabol, zabol, ir iran; department of biology, faculty of science, university of zabol, zabol, ir iran. tel 98-5432234983, fax 98-5432213430
سازمان اصلی تایید شده: دانشگاه زابل (Zabol university)
بهمن هرمزی | bahman hormozi
department of biology, faculty of science, university of zabol, zabol, ir iran
سازمان اصلی تایید شده: دانشگاه زابل (Zabol university)
محسن نجیمی | mohsen najimi
department of physiopathology, faculty of veterinary medicine, university of zabol, zabol, ir iran
سازمان اصلی تایید شده: دانشگاه زابل (Zabol university)
نفیسه نورزهی | nafiseh noorzehi
department of biology, faculty of science, university of zabol, zabol, ir iran
سازمان اصلی تایید شده: دانشگاه زابل (Zabol university)
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| نشانی اینترنتی |
http://www.ajcmicrob.com/index.php?page=article&article_id=30656 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/1795/article-1795-276897.pdf |
| کد مقاله (doi) |
10.17795/ajcmi-30656 |
| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
research-article |
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