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Avicenna Journal of Clinical Microbiology and Infection، جلد ۴، شماره ۱، صفحات ۰-۰
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| عنوان فارسی |
Antimicrobial Effects of Ferula persica Gum Extract and Gold Nanoparticles on Pseudomonas aeruginosa |
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| چکیده فارسی مقاله |
Conclusions The results of the present study showed that the extract of F. persica gum and the gold nanoparticles had anti-Pseudomonas aeruginosa effects, which were more pronounced when they were used separately. Objectives The present study aimed to evaluate the anti-bacterial effects of Ferula persica gum extract and gold nanoparticles on P. aeruginosa strains isolated from burn wound infections in Isfahan in 2012. Materials and Methods In this experimental study, 150 P. aeruginosa strains carrying the blaSPM-1 gene were isolated from burn wound infections and were confirmed by biochemical tests. The anti-microbial activities of Ferula persica gum extract and gold nanoparticles were evaluated by agar well-diffusion assay and microdilution antimicrobial susceptibility tests. The results were compared to ciprofloxacin. Results The highest mean zone of inhibition (18 mm) was observed in a concentration of 250 mg/mL of F. persica extract, which was equal to that of ciprofloxacin. In the gold nanoparticles, the highest mean growth inhibition zone (10.18 mm) was observed in the dilution of 50 ppm. The highest zone of inhibition of nanoparticle-extract synergy was observed in the dilution of 125 mg/mL extract + 25 ppm nanoparticle (9.89 mm). The MIC and MBC of the extract were 69.25 ± 42.36 mg/mL and 102.25 ± 16.76 mg/mL, respectively. The MIC and MBC of the nanoparticle-extract mixture were 50.78 ± 19.26 mg/mL and 54.11 ± 19.72 mg/mL, respectively. Background In the treatment of bacterial infections, drug resistance is a global problem; Pseudomonas aeruginosa is no exception. This bacterium is among the important causes of nosocomial infections, especially burn wound infections, and it is resistant to most applicable antibiotics. |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Antimicrobial Effects of Ferula persica Gum Extract and Gold Nanoparticles on Pseudomonas aeruginosa |
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| چکیده انگلیسی مقاله |
Conclusions The results of the present study showed that the extract of F. persica gum and the gold nanoparticles had anti-Pseudomonas aeruginosa effects, which were more pronounced when they were used separately. Objectives The present study aimed to evaluate the anti-bacterial effects of Ferula persica gum extract and gold nanoparticles on P. aeruginosa strains isolated from burn wound infections in Isfahan in 2012. Materials and Methods In this experimental study, 150 P. aeruginosa strains carrying the blaSPM-1 gene were isolated from burn wound infections and were confirmed by biochemical tests. The anti-microbial activities of Ferula persica gum extract and gold nanoparticles were evaluated by agar well-diffusion assay and microdilution antimicrobial susceptibility tests. The results were compared to ciprofloxacin. Results The highest mean zone of inhibition (18 mm) was observed in a concentration of 250 mg/mL of F. persica extract, which was equal to that of ciprofloxacin. In the gold nanoparticles, the highest mean growth inhibition zone (10.18 mm) was observed in the dilution of 50 ppm. The highest zone of inhibition of nanoparticle-extract synergy was observed in the dilution of 125 mg/mL extract + 25 ppm nanoparticle (9.89 mm). The MIC and MBC of the extract were 69.25 ± 42.36 mg/mL and 102.25 ± 16.76 mg/mL, respectively. The MIC and MBC of the nanoparticle-extract mixture were 50.78 ± 19.26 mg/mL and 54.11 ± 19.72 mg/mL, respectively. Background In the treatment of bacterial infections, drug resistance is a global problem; Pseudomonas aeruginosa is no exception. This bacterium is among the important causes of nosocomial infections, especially burn wound infections, and it is resistant to most applicable antibiotics. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
بهاره نصراللهی نژاد | bahareh nasrollahi nejad
biology department, basic sciences faculty, shahrekord branch, islamic azad university, shahrekord, ir iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)
زهرا بم زاده | zahra bamzadeh
biology department, basic sciences faculty, shahrekord branch, islamic azad university, shahrekord, ir iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)
سید حسین حجازی | seyed hossein hejazi
skin disease and leishmaniasis research center, department of parasitology and mycology, school of medicine, isfahan university of medical sciences, isfahan, ir iran; skin disease and leishmaniasis research center, department of parasitology and mycology, school of medicine, isfahan university of medical sciences, isfahan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)
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| نشانی اینترنتی |
http://www.ajcmicrob.com/index.php?page=article&article_id=36646 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
10.17795/ajcmi-36646 |
| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
research-article |
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