Avicenna Journal of Dental Research، جلد 8، شماره 2، صفحات 0-0
عنوان فارسی Immunohistochemical Evaluation of Ki-67 Expression in Erosive and Non-Erosive Oral Lichen Planus
چکیده فارسی مقاله Conclusions Since Ki-67 is extensively accepted as an important biomarker in diagnosis, prognosis and treatment of cancerous and precancerous lesions, a high degree of presence of this biomarker in chronic precancerous lesions, such as erosive OLP, can be of great use in prognosis and suggested treatments. Objectives This study aimed to evaluate Ki-67 expression in erosive and non-erosive oral lichen planus. Materials and Methods Specimens (formalin-fixed and paraffin-embedded) of 30 lesions of erosive OLP and 30 lesions of non-erosive OLP were referred for immunehistochemistry (IHC) analysis of Ki-67. Results of immunohistochemistry were statistically evaluated by means of the chi-square test and independent t-test. The level of statistical significance was established at P < 0.05. Background Oral lichen planus (OLP) is a relatively common, chronic inflammatory condition, which is considered a precancerous lesion. The Ki-67 antigen is expressed in all the phases of the cellular cycle in proliferative cells. Different studies have suggested the relationship between incidences of malignancy in precancerous lesions and the occurrence of this protein. Results The mean expression of Ki-67 in patients with erosive OLP was higher than people in the control group. These differences were statistically significant (P = 0.041).
کلیدواژه‌های فارسی مقاله Lichen Planus،Oral،Ki67،Immunohistochemistry
عنوان انگلیسی Immunohistochemical Evaluation of Ki-67 Expression in Erosive and Non-Erosive Oral Lichen Planus
چکیده انگلیسی مقاله Conclusions Since Ki-67 is extensively accepted as an important biomarker in diagnosis, prognosis and treatment of cancerous and precancerous lesions, a high degree of presence of this biomarker in chronic precancerous lesions, such as erosive OLP, can be of great use in prognosis and suggested treatments. Objectives This study aimed to evaluate Ki-67 expression in erosive and non-erosive oral lichen planus. Materials and Methods Specimens (formalin-fixed and paraffin-embedded) of 30 lesions of erosive OLP and 30 lesions of non-erosive OLP were referred for immunehistochemistry (IHC) analysis of Ki-67. Results of immunohistochemistry were statistically evaluated by means of the chi-square test and independent t-test. The level of statistical significance was established at P < 0.05. Background Oral lichen planus (OLP) is a relatively common, chronic inflammatory condition, which is considered a precancerous lesion. The Ki-67 antigen is expressed in all the phases of the cellular cycle in proliferative cells. Different studies have suggested the relationship between incidences of malignancy in precancerous lesions and the occurrence of this protein. Results The mean expression of Ki-67 in patients with erosive OLP was higher than people in the control group. These differences were statistically significant (P = 0.041).
کلیدواژه‌های انگلیسی مقاله Lichen Planus,Oral,Ki67,Immunohistochemistry
نویسندگان مقاله narges gholizadeh - department of oral medicine, faculty of dentistry, tehran university of medical sciences, tehran, ir iran

masoumeh mehdipour - department of oral medicine, faculty of dentistry, shahid beheshti university of medical sciences, tehran, ir iran

esmaiil dadgar - dentist, tabriz, ir iran

ayla bahramian - department of oral medicine, faculty of dentistry, tabriz university of medical sciences, tabriz, ir iran; department of oral medicine, faculty of dentistry, tabriz university of medical sciences, tabriz, ir iran

delaram ebrahimpour moghaddas - department of oral medicine, faculty of dentistry, zanjan university of medical sciences, zanjan, ir iran

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کد مقاله (doi) 10.17795/ajdr-25372
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