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Avicenna Journal of Dental Research، جلد ۸، شماره ۲، صفحات ۰-۰
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| عنوان فارسی |
Immunohistochemical Study of Estrogen Receptor Expression in Adenoid Cystic Carcinoma and Mucoepidermoid Carcinoma of the Salivary Gland |
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| چکیده فارسی مقاله |
Conclusions Regarding the findings of this study, it can be concluded that ERα possibly cannot play an important role in the tumorigenesis and prognosis of the investigated malignant salivary gland tumors. Results For ACC, only one specimen expressed the ER, and this was assessed as moderate. No specimens of MEC expressed the ER. The comparison of ER expression between the two groups was not meaningful (P = 0.99). Background Estrogen as a steroid hormone plays a role in the differentiation and growth of various tissues, such as the breast, endometrium, colon, and prostate, as well as their cancers. The literature offers different and partly contradictory findings concerning the investigations of estrogen receptor (ER) expression in salivary gland tumors. Objectives The aim of this study was to investigate the expression of ER in two main types of malignant salivary gland tumors, namely adenoid cystic carcinoma (ACC) and mucoepidermoid carcinoma (MEC), in an Iranian population using immunohistochemical techniques. Patients and Methods After reviewing the patients’ records in the departments of pathology in some hospitals in the city of Yazd covering all native and southern-region patients, out of all malignant salivary glands tumors, 40 specimens were retrieved. These included 24 ACCs and 16 MECs. Following the preparation of 4 μm sections and the deparaffinization and dehydration steps, the immunohistochemical process was conducted using the antibody against estrogen receptor α (Clone1D5, DAKO, Denmark). The prepared slides were then observed under a light microscope, and the stained nuclei were counted. The data were analyzed using SPSS 17 and the generalized Fisher exact test. |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Immunohistochemical Study of Estrogen Receptor Expression in Adenoid Cystic Carcinoma and Mucoepidermoid Carcinoma of the Salivary Gland |
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| چکیده انگلیسی مقاله |
Conclusions Regarding the findings of this study, it can be concluded that ERα possibly cannot play an important role in the tumorigenesis and prognosis of the investigated malignant salivary gland tumors. Results For ACC, only one specimen expressed the ER, and this was assessed as moderate. No specimens of MEC expressed the ER. The comparison of ER expression between the two groups was not meaningful (P = 0.99). Background Estrogen as a steroid hormone plays a role in the differentiation and growth of various tissues, such as the breast, endometrium, colon, and prostate, as well as their cancers. The literature offers different and partly contradictory findings concerning the investigations of estrogen receptor (ER) expression in salivary gland tumors. Objectives The aim of this study was to investigate the expression of ER in two main types of malignant salivary gland tumors, namely adenoid cystic carcinoma (ACC) and mucoepidermoid carcinoma (MEC), in an Iranian population using immunohistochemical techniques. Patients and Methods After reviewing the patients’ records in the departments of pathology in some hospitals in the city of Yazd covering all native and southern-region patients, out of all malignant salivary glands tumors, 40 specimens were retrieved. These included 24 ACCs and 16 MECs. Following the preparation of 4 μm sections and the deparaffinization and dehydration steps, the immunohistochemical process was conducted using the antibody against estrogen receptor α (Clone1D5, DAKO, Denmark). The prepared slides were then observed under a light microscope, and the stained nuclei were counted. The data were analyzed using SPSS 17 and the generalized Fisher exact test. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
سید حسین طباطبایی | seyed hossein tabatabaei
department of oral and maxillofacial pathology, shahid sadoughi university of medical sciences, yazd, ir iran
نجمه جعفری | najmeh jafari
department of oral and maxillofacial pathology, shahid sadoughi university of medical sciences, yazd, ir iran; department of oral and maxillofacial pathology, shahid sadoughi university of medical sciences, yazd, ir iran. tel 98-9131592128, fax 98-3516250344
محمود اخوان تفتی | mahmood akhavan tafti
department of pathology, shahid sadoughi university of medical sciences, yazd, ir iran
علی توکلی حسینی | ali tavakoli hosseini
department of oral and maxillofacial pathology, shahid sadoughi university of medical sciences, yazd, ir iran
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| نشانی اینترنتی |
http://www.avicennajdr.com/index.php?page=article&article_id=26715 |
| فایل مقاله |
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| کد مقاله (doi) |
10.17795/ajdr-26715 |
| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
1 |
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