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Avicenna Journal of Dental Research، جلد 6، شماره 1، صفحات 0-0
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| عنوان فارسی |
Controlled Release of Drugs for Management of Pulpitis |
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| چکیده فارسی مقاله |
Context Biocompatible polymers are potentially effective for dental infections as delivery carriers of disinfectants or antibiotics into the root canal system (RCS). This study aimed to review polymeric microspheres enabling a controlled release of endodontic medicaments. Evidence Acquisition A literature search was carried out in the PubMed database (May 2013) using the following keywords: “poly lactic-co-glycolic acid or PLGA”, “polymer microplate”, “encapsulate”, “drug delivery”, “controlled release”, “antibiotic”, “gentamycin”, and “amoxicillin”. We intended to find articles on the application of polymer microparticles for delivery and release of drugs in dental infections or articles discussing factors affecting the properties of these materials. Results Seventeen articles were found evaluating the controlled release of the drugs for dental purposes; out of them, in 5 in vitro studies, polymer microspheres had been produced for root canal disinfection. Seven articles had investigated the properties of polymer microspheres and the factors influencing drug release by them. Conclusions Drug-loaded polymer microspheres may be used successfully as delivery carriers for controlled release of antibiotics into the root canal system. The efficacy and success rate of this method must be tested in animal models and then clinical trials. |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Controlled Release of Drugs for Management of Pulpitis |
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| چکیده انگلیسی مقاله |
Context Biocompatible polymers are potentially effective for dental infections as delivery carriers of disinfectants or antibiotics into the root canal system (RCS). This study aimed to review polymeric microspheres enabling a controlled release of endodontic medicaments. Evidence Acquisition A literature search was carried out in the PubMed database (May 2013) using the following keywords: “poly lactic-co-glycolic acid or PLGA”, “polymer microplate”, “encapsulate”, “drug delivery”, “controlled release”, “antibiotic”, “gentamycin”, and “amoxicillin”. We intended to find articles on the application of polymer microparticles for delivery and release of drugs in dental infections or articles discussing factors affecting the properties of these materials. Results Seventeen articles were found evaluating the controlled release of the drugs for dental purposes; out of them, in 5 in vitro studies, polymer microspheres had been produced for root canal disinfection. Seven articles had investigated the properties of polymer microspheres and the factors influencing drug release by them. Conclusions Drug-loaded polymer microspheres may be used successfully as delivery carriers for controlled release of antibiotics into the root canal system. The efficacy and success rate of this method must be tested in animal models and then clinical trials. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
zahra jaberi ansari - department of operative dentistry, dental school, shahid beheshti university of medical sciences, tehran, ir iran
malihe ekrami - department of operative dentistry, dental school, shahid beheshti university of medical sciences, tehran, ir iran
hanieh nojehdehian - department of dental materials, dental school, shahid beheshti university of medical sciences, tehran, ir iran; department of dental materials, dental school, shahid beheshti university of medical sciences, tehran, ir iran. tel 98-2122173754 fax 98-2122173754
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| نشانی اینترنتی |
http://www.avicennajdr.com/index.php?page=article&article_id=21610 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
10.17795/ajdr-21610 |
| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
3 |
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