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Avicenna Journal of Dental Research، جلد 5، شماره 1، صفحات 0-0
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| عنوان فارسی |
Type and Portions of Peripheral Blood T Lymphocytes in Oral Lichen Planus |
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| چکیده فارسی مقاله |
Background Lichen planus is a disease with unknown etiology that affects the skin and the mucous membranes. Immune dysregulation in the pathogenesis of oral lichen planus (OLP) is well-known phenomenon. Objectives In this study, we compared the levels of the peripheral blood T lymphocytes between patients with OLP and control group. Patients and Methods In this study, 32 and 16 patients respectively with and without OLP were recruited. Five milliliters of the participants' peripheral venous blood was drew in an EDTA-containing test tube and the levels of CD3+, CD4+, and CD8+ cells, CD4+/CD8+ and CD4+/CD3+ ratio were measured by means of two-color flow cytometry. The data were analyzed in SPPS v.19 by employing Mann-Whitney U test. Results There were no significant difference among the levels of CD3+, CD4+, and CD8+ lymphocytes and the ratio of CD4+/CD8+ and CD4+/CD3+ lymphocytes between patients and control group; however, there was a significant difference between male and female patients with respect to the levels of CD3+ and CD4+ lymphocytes and the ratio of CD4+/CD8+ and CD4+/CD3+ lymphocytes. Conclusions Our results confirm that only local immune mechanism known as skin-associated lymphoid tissue, not a systemic immunologic disorder, was involved in the OLP. |
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| کلیدواژه‌های فارسی مقاله |
Lichen Planus،T-Lymphocytes،Peripheral Blood |
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| عنوان انگلیسی |
Type and Portions of Peripheral Blood T Lymphocytes in Oral Lichen Planus |
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| چکیده انگلیسی مقاله |
Background Lichen planus is a disease with unknown etiology that affects the skin and the mucous membranes. Immune dysregulation in the pathogenesis of oral lichen planus (OLP) is well-known phenomenon. Objectives In this study, we compared the levels of the peripheral blood T lymphocytes between patients with OLP and control group. Patients and Methods In this study, 32 and 16 patients respectively with and without OLP were recruited. Five milliliters of the participants' peripheral venous blood was drew in an EDTA-containing test tube and the levels of CD3+, CD4+, and CD8+ cells, CD4+/CD8+ and CD4+/CD3+ ratio were measured by means of two-color flow cytometry. The data were analyzed in SPPS v.19 by employing Mann-Whitney U test. Results There were no significant difference among the levels of CD3+, CD4+, and CD8+ lymphocytes and the ratio of CD4+/CD8+ and CD4+/CD3+ lymphocytes between patients and control group; however, there was a significant difference between male and female patients with respect to the levels of CD3+ and CD4+ lymphocytes and the ratio of CD4+/CD8+ and CD4+/CD3+ lymphocytes. Conclusions Our results confirm that only local immune mechanism known as skin-associated lymphoid tissue, not a systemic immunologic disorder, was involved in the OLP. |
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| کلیدواژه‌های انگلیسی مقاله |
Lichen Planus,T-Lymphocytes,Peripheral Blood |
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| نویسندگان مقاله |
seyed javad kia - department of oral medicine, guilan university of medical sciences, rasht, ir iran
arash mansourian - department of oral medicine, tehran university of medical sciences, tehran, ir iran; department of oral medicine, tehran university of medical sciences, tehran, ir iran. tel 98-9123344090, fax 98-2188497416
masoumeh nikkhah - dentist, private practice, tehran, ir iran
nariman nikparto - students amp; 039; scientific research center, tehran university of medical sciences, tehran, ir iran
najmeh shanbezadeh - dentist, private practice, tehran, ir iran
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| نشانی اینترنتی |
http://www.avicennajdr.com/index.php?page=article&article_id=20187 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
10.17795/ajdr-20187 |
| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
1 |
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