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Avicenna Journal of Medical Biochemistry، جلد ۴، شماره ۲، صفحات ۰-۰
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| عنوان فارسی |
The Effects of Different Types of Chronic Stress on Morphometric Changes and Apoptosis of Betz Cells in the Internal Pyramidal Layer of the Cerebral Cortex of Rats |
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| چکیده فارسی مقاله |
Results The mean number and size of Betz cells in the stressed group decreased significantly compared to those in the control group (P < 0.05). Qualitative observations revealed chromatolysis of Nissl bodies, nucleus condensation, and a decrease in neural processes. The mean number of apoptotic cells in the stressed group were also significantly increased compared to that of the control group (P < 0.001). Conclusions The results showed that chronic multiple sequential stress can have negative effects on the cerebral cortex of rats by reducing the size and number of Betz cells and increasing the incidence of apoptosis. More studies are needed to confirm these results. Background Technology-induced increases in stress can have adverse effects on the nervous system. Objectives The aim of the present study was to investigate the effects of chronic multiple stressors on morphometric changes in Betz cells in the rat cerebral cortex. Methods Eighteen Wistar rats were divided randomly into two equal groups. One group was then exposed to different types of stress (forced swimming, restraint, water deprivation, isolation, and food deprivation) for 10 days, and the other group (control) remained in cages and was not exposed to any stress. The animals were then weighed and anesthetized, and their brains were removed and weighed. After fixation, the brain samples were prepared for light microscopy study. The number, size, and incidence of apoptosis of Betz cells in the internal pyramidal layer were determined using the ImageTool software program, and the data were analyzed using SPSS software and a t-test, with a value of P < 0.05 considered statistically significant. |
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| کلیدواژه‌های فارسی مقاله |
Apoptosis،Brain،Pyramidal Cells،Rats،Stress |
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| عنوان انگلیسی |
The Effects of Different Types of Chronic Stress on Morphometric Changes and Apoptosis of Betz Cells in the Internal Pyramidal Layer of the Cerebral Cortex of Rats |
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| چکیده انگلیسی مقاله |
Results The mean number and size of Betz cells in the stressed group decreased significantly compared to those in the control group (P < 0.05). Qualitative observations revealed chromatolysis of Nissl bodies, nucleus condensation, and a decrease in neural processes. The mean number of apoptotic cells in the stressed group were also significantly increased compared to that of the control group (P < 0.001). Conclusions The results showed that chronic multiple sequential stress can have negative effects on the cerebral cortex of rats by reducing the size and number of Betz cells and increasing the incidence of apoptosis. More studies are needed to confirm these results. Background Technology-induced increases in stress can have adverse effects on the nervous system. Objectives The aim of the present study was to investigate the effects of chronic multiple stressors on morphometric changes in Betz cells in the rat cerebral cortex. Methods Eighteen Wistar rats were divided randomly into two equal groups. One group was then exposed to different types of stress (forced swimming, restraint, water deprivation, isolation, and food deprivation) for 10 days, and the other group (control) remained in cages and was not exposed to any stress. The animals were then weighed and anesthetized, and their brains were removed and weighed. After fixation, the brain samples were prepared for light microscopy study. The number, size, and incidence of apoptosis of Betz cells in the internal pyramidal layer were determined using the ImageTool software program, and the data were analyzed using SPSS software and a t-test, with a value of P < 0.05 considered statistically significant. |
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| کلیدواژه‌های انگلیسی مقاله |
Apoptosis,Brain,Pyramidal Cells,Rats,Stress |
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| نویسندگان مقاله |
طوفان صابرنیا | toofan sabernia
department of anatomy, school of medicine, qazvin university of medical sciences, qazvin, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی قزوین (Qazvin university of medical sciences)
حسین پیری | hossein piri
cellular and molecular research center, qazvin university of medical sciences, qazvin, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی قزوین (Qazvin university of medical sciences)
فرزاد رجایی | farzad rajaei
cellular and molecular research center, qazvin university of medical sciences, qazvin, ir iran; cellular and molecular research center, faculty of medicine, bahonar boulevard, qazvin university of medical sciences, qazvin, ir iran. tel 98-912281742, fax 98-281-3324970
سازمان اصلی تایید شده: دانشگاه علوم پزشکی قزوین (Qazvin university of medical sciences)
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| نشانی اینترنتی |
http://www.avicennajb.com/index.php?page=article&article_id=33530 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
10.17795/ajmb-33530 |
| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
research-article |
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