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Avicenna Journal of Medical Biochemistry، جلد 4، شماره 2، صفحات 0-0
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| عنوان فارسی |
The Effect of Silver Nanoparticles on the Biochemical Parameters of Liver Function in Serum, and the Expression of Caspase-3 in the Liver Tissues of Male Rats |
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| چکیده فارسی مقاله |
Conclusions Based on the present study, it can be concluded that oral administration of silver nanoparticles for 28 days had no effect on rat liver function, but probably led to early apoptotic stages. Materials and Methods In this experimental study, 40 adult male Sprague-Dawley rats were divided into five groups. In the four experimental groups, nanosilver particles were given orally for 28 consecutive days at doses of 30, 125, 300, or 700 mg/kg. Rats in the control group received equal volumes of deionized water. To evaluate the expression of caspase-3 in liver tissue, the real-time PCR method was used. Albumin, total protein, total bilirubin, alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase were measured with an RA-1000 autoanalyzer. Results The results indicated that caspase-3 was upregulated in the treated groups compared to the control group (P < 0.05). No considerable changes in serum biochemical parameters were observed (P > 0.05). Background Silver nanoparticles have antibacterial properties and their use is growing in different industries. Since the toxicity of nanosilver is not well known, it is essential to examine its safety. Objectives This experiment was undertaken to study the effects of nanosilver on rat liver function with an evaluation of blood biochemistry parameters and caspase-3 expression in the liver. |
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| کلیدواژه‌های فارسی مقاله |
Apoptosis،Caspase-3،Liver،Nanoparticles،Silver |
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| عنوان انگلیسی |
The Effect of Silver Nanoparticles on the Biochemical Parameters of Liver Function in Serum, and the Expression of Caspase-3 in the Liver Tissues of Male Rats |
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| چکیده انگلیسی مقاله |
Conclusions Based on the present study, it can be concluded that oral administration of silver nanoparticles for 28 days had no effect on rat liver function, but probably led to early apoptotic stages. Materials and Methods In this experimental study, 40 adult male Sprague-Dawley rats were divided into five groups. In the four experimental groups, nanosilver particles were given orally for 28 consecutive days at doses of 30, 125, 300, or 700 mg/kg. Rats in the control group received equal volumes of deionized water. To evaluate the expression of caspase-3 in liver tissue, the real-time PCR method was used. Albumin, total protein, total bilirubin, alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase were measured with an RA-1000 autoanalyzer. Results The results indicated that caspase-3 was upregulated in the treated groups compared to the control group (P < 0.05). No considerable changes in serum biochemical parameters were observed (P > 0.05). Background Silver nanoparticles have antibacterial properties and their use is growing in different industries. Since the toxicity of nanosilver is not well known, it is essential to examine its safety. Objectives This experiment was undertaken to study the effects of nanosilver on rat liver function with an evaluation of blood biochemistry parameters and caspase-3 expression in the liver. |
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| کلیدواژه‌های انگلیسی مقاله |
Apoptosis,Caspase-3,Liver,Nanoparticles,Silver |
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| نویسندگان مقاله |
mahsa pourhamzeh - students research center, hamadan university of medical sciences, hamadan, ir iran
zahra gholami mahmoudian - students research center, hamadan university of medical sciences, hamadan, ir iran
massoud saidijam - research center for molecular medicine, hamadan university of medical sciences, hamadan, ir iran
mohamad javad asari - department of environmental and occupational health, school of public health, hamadan university of medical sciences, hamadan, ir iran
zohreh alizadeh - endometrium and endometriosis research center, hamadan university of medical sciences, hamadan, ir iran; department of anatomical sciences, school of medicine, hamadan university of medical sciences, hamadan, ir iran. tel 98-9181110700
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| نشانی اینترنتی |
http://www.avicennajb.com/index.php?page=article&article_id=35557 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
10.17795/ajmb-35557 |
| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
research-article |
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