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Avicenna Journal of Medical Biochemistry، جلد ۴، شماره ۲، صفحات ۰-۰
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| عنوان فارسی |
Cord Blood Butyrylcholinesterase Activities in Normal Pregnant and Preeclamptic Women |
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| چکیده فارسی مقاله |
Background Human placenta, a non-neural tissue, contains cholinergic system and high-affinity muscarinic receptors. The role of cholinesterases (CE) in trophoblast function and pregnancy is not clear. Objectives The present study aimed to analyze cholinesterase (CE) levels in cord blood in preeclamptic women. Methods In the present study, maternal and cord blood butyrylcholinesterase levels were analyzed in women with preeclampsia (n = 25) and compared to those of normotensive pregnant women (n = 25) and normal, non-pregnant healthy controls (n = 25) by a kinetic method (the new DGKC method) using the AutoAnalyzer. Results In the present study, maternal butyrylcholinesterase levels were lower in preeclamptics as compared to normotensive controls. Butyrylcholinesterase levels were lower in the cord blood of the babies of normotensives, amounting to 88.65% of the maternal levels. Cord blood butyrylcholinesterase levels were significantly lower in preeclamptic pregnant women as compared to normotensive pregnant women. On comparing these butyrylcholinesterase levels to the normal, non-pregnant control (Group III), it was observed that CE levels were significantly lower in both normotensive and preeclamptic women. Conclusions The findings of the present study indicate that butyrylcholinesterase levels are lower in preeclamptics and that this might be due to the loss of muscarinic cholinergic receptors that occurs in preeclampsia. |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Cord Blood Butyrylcholinesterase Activities in Normal Pregnant and Preeclamptic Women |
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| چکیده انگلیسی مقاله |
Background Human placenta, a non-neural tissue, contains cholinergic system and high-affinity muscarinic receptors. The role of cholinesterases (CE) in trophoblast function and pregnancy is not clear. Objectives The present study aimed to analyze cholinesterase (CE) levels in cord blood in preeclamptic women. Methods In the present study, maternal and cord blood butyrylcholinesterase levels were analyzed in women with preeclampsia (n = 25) and compared to those of normotensive pregnant women (n = 25) and normal, non-pregnant healthy controls (n = 25) by a kinetic method (the new DGKC method) using the AutoAnalyzer. Results In the present study, maternal butyrylcholinesterase levels were lower in preeclamptics as compared to normotensive controls. Butyrylcholinesterase levels were lower in the cord blood of the babies of normotensives, amounting to 88.65% of the maternal levels. Cord blood butyrylcholinesterase levels were significantly lower in preeclamptic pregnant women as compared to normotensive pregnant women. On comparing these butyrylcholinesterase levels to the normal, non-pregnant control (Group III), it was observed that CE levels were significantly lower in both normotensive and preeclamptic women. Conclusions The findings of the present study indicate that butyrylcholinesterase levels are lower in preeclamptics and that this might be due to the loss of muscarinic cholinergic receptors that occurs in preeclampsia. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
simmi kharb | simmi kharb
pt. b.d. sharma pgims, rohtak, haryana, india; pt. b.d. sharma pgims, rohtak, haryana, india. tel 91-9812016036
prerna panjeta | prerna panjeta
bps government medical college for women, khanpur kalan, sonepat, india
vikram kala | vikram kala
bps government medical college for women, khanpur kalan, sonepat, india
vs ghalaut | vs ghalaut
pt. b.d. sharma pgims, rohtak, haryana, india
jyoti بالا | jyoti bala
pt. b.d. sharma pgims, rohtak, haryana, india
smiti nanda | smiti nanda
pt. b.d. sharma pgims, rohtak, haryana, india
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| نشانی اینترنتی |
http://www.avicennajb.com/index.php?page=article&article_id=39507 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
10.17795/ajmb-39507 |
| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
research-article |
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