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Avicenna Journal of Medical Biochemistry، جلد ۳، شماره ۱، صفحات ۰-۰
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| عنوان فارسی |
Therapeutic Effect of Silybum marianum Plant Extract on Tamoxifen-Induced Fatty Liver in Rats |
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| چکیده فارسی مقاله |
Conclusions Intake of water extract of Silybum marianum is a useful treatment for liver function in drug-induced fatty liver. Results Concentrations of HDL-C and protein decreased and activity of ALT increased in TMX group compared with the control group. The SME increased protein concentration and decreased ALT activity in TMX-SME group compared with the TMX group. Histopathological examination and triglyceride assay in liver tissues showed lipid accumulation in the TMX-treated rats and amelioration of lipid accumulation in the liver of TMX-SME-treated rats. Materials and Methods Adult female Wistar rats were divided to four groups; 1) normal control untreated rats, 2) SME-treated rats, that received only SME in a dose of 1.6 g/kg body weight/day, oral gavage for 14 days, 3) TMX-treated rats, that received TMX in a dose of 1 mg/kg body weight/day, subcutaneously, for seven days, 4) TMX-SME-treated rats, that received TMX in a dose of 1 mg/kg body weight/day, subcutaneously, for seven days and then SME by oral gavage for 14 days. The groups were compared in terms of serum glucose, triglyceride, cholesterol, Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), Alkaline Phosphatase (ALP), High-Density Lipoprotein-Cholesterol (HDL-C), Low-Density Lipoprotein-Cholesterol (LDL-C), total protein and liver triglyceride amount, and histological findings. Objectives In this study the effect of Silybum marianum Extract (SME) on histological and biochemical parameters in TMX-treated rats was investigated. Background Tamoxifen (TMX) is a synthetic drug that is widely used for treatment of breast cancer. Despite the beneficial effects of TMX, the use of this drug has several side effects such as the development of Non-Alcoholic Fatty Liver Disease (NAFLD) in the patients. Silybum marianum is the most researched plant in treatment of liver disease. |
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| کلیدواژه‌های فارسی مقاله |
Fatty Liver،Tamoxifen،Silybum marianum |
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| عنوان انگلیسی |
Therapeutic Effect of Silybum marianum Plant Extract on Tamoxifen-Induced Fatty Liver in Rats |
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| چکیده انگلیسی مقاله |
Conclusions Intake of water extract of Silybum marianum is a useful treatment for liver function in drug-induced fatty liver. Results Concentrations of HDL-C and protein decreased and activity of ALT increased in TMX group compared with the control group. The SME increased protein concentration and decreased ALT activity in TMX-SME group compared with the TMX group. Histopathological examination and triglyceride assay in liver tissues showed lipid accumulation in the TMX-treated rats and amelioration of lipid accumulation in the liver of TMX-SME-treated rats. Materials and Methods Adult female Wistar rats were divided to four groups; 1) normal control untreated rats, 2) SME-treated rats, that received only SME in a dose of 1.6 g/kg body weight/day, oral gavage for 14 days, 3) TMX-treated rats, that received TMX in a dose of 1 mg/kg body weight/day, subcutaneously, for seven days, 4) TMX-SME-treated rats, that received TMX in a dose of 1 mg/kg body weight/day, subcutaneously, for seven days and then SME by oral gavage for 14 days. The groups were compared in terms of serum glucose, triglyceride, cholesterol, Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), Alkaline Phosphatase (ALP), High-Density Lipoprotein-Cholesterol (HDL-C), Low-Density Lipoprotein-Cholesterol (LDL-C), total protein and liver triglyceride amount, and histological findings. Objectives In this study the effect of Silybum marianum Extract (SME) on histological and biochemical parameters in TMX-treated rats was investigated. Background Tamoxifen (TMX) is a synthetic drug that is widely used for treatment of breast cancer. Despite the beneficial effects of TMX, the use of this drug has several side effects such as the development of Non-Alcoholic Fatty Liver Disease (NAFLD) in the patients. Silybum marianum is the most researched plant in treatment of liver disease. |
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| کلیدواژه‌های انگلیسی مقاله |
Fatty Liver,Tamoxifen,Silybum marianum |
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| نویسندگان مقاله |
حمید behrouj | hamid behrouj
department of clinical biochemistry, school of medicine, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
نسرین ضیامجیدی | nasrin ziamajidi
department of clinical biochemistry, school of medicine, hamadan university of medical sciences, hamadan, ir iran; department of clinical biochemistry, school of medicine, hamadan university of medical sciences, hamadan, ir iran. tel 98-8138380574
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
رقیه عباسعلی پورکبیر | roghayeh abbasalipourkabir
department of clinical biochemistry, school of medicine, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
ابوالفضل نصیری | abolfazl nasiri
department of clinical biochemistry, school of medicine, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
سارا سلیمانی اصل | sara soleimani asl
department of anatomy, school of medicine, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
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| نشانی اینترنتی |
http://www.avicennajb.com/index.php?page=article&article_id=27160 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
10.17795/ajmb-27160 |
| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
research-article |
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