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Avicenna Journal of Medical Biochemistry، جلد ۳، شماره ۱، صفحات ۰-۰
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| عنوان فارسی |
The Impact of G۱۵۷۵A Matrix Metalloprotease-۲ Gene Polymorphism on Male Fertility |
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| چکیده فارسی مقاله |
Results Genotype frequencies of G/A in fertile and infertile men were significantly different (χ2 = 4.16, df = 1, p = 0.041). Genotype frequencies of G/G and A/Ain fertile and infertile men were not significantly different (χ2 = 3.32, df = 1, P = 0.068 and χ2 = 0.521, df = 1, P = 0.47, respectively). The risk of infertility was 1.43 folds higher in individuals with the A/A genotype compared to those with the G/G genotype. In men with the A/A genotype the risk of infertility was 2.14 folds higher than individuals with the G/A genotype. Objectives The aim of this study was to investigate the prevalence of G1575A matrix metalloproteinase-2 gene polymorphism in fertile and infertile men. Patients and Methods In this study 200 fertile men as controls and 200 idiopathic infertile men as cases were investigated. For genotyping thefertile and infertile group the Polymerase Chain Reaction–Restriction Fragment Length Polymorphism (PCR-RFLP) method was used. Background Matrix metalloproteinases contain more than 20 enzymes that require zinc for their activities. Gelatinases are one of the subtypes of matrixmetalloproteinases, which degrade gelatin and collagen type 4, and are present in male reproductive tissues such as in prostate. G1575A Matrix Metalloproteinase-2 (MMP-2) gene polymorphism affects MMP-2 activity. Conclusions These finding suggests that genetic variation of MMP can affect male infertility. |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
The Impact of G1575A Matrix Metalloprotease-2 Gene Polymorphism on Male Fertility |
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| چکیده انگلیسی مقاله |
Results Genotype frequencies of G/A in fertile and infertile men were significantly different (χ2 = 4.16, df = 1, p = 0.041). Genotype frequencies of G/G and A/Ain fertile and infertile men were not significantly different (χ2 = 3.32, df = 1, P = 0.068 and χ2 = 0.521, df = 1, P = 0.47, respectively). The risk of infertility was 1.43 folds higher in individuals with the A/A genotype compared to those with the G/G genotype. In men with the A/A genotype the risk of infertility was 2.14 folds higher than individuals with the G/A genotype. Objectives The aim of this study was to investigate the prevalence of G1575A matrix metalloproteinase-2 gene polymorphism in fertile and infertile men. Patients and Methods In this study 200 fertile men as controls and 200 idiopathic infertile men as cases were investigated. For genotyping thefertile and infertile group the Polymerase Chain Reaction–Restriction Fragment Length Polymorphism (PCR-RFLP) method was used. Background Matrix metalloproteinases contain more than 20 enzymes that require zinc for their activities. Gelatinases are one of the subtypes of matrixmetalloproteinases, which degrade gelatin and collagen type 4, and are present in male reproductive tissues such as in prostate. G1575A Matrix Metalloproteinase-2 (MMP-2) gene polymorphism affects MMP-2 activity. Conclusions These finding suggests that genetic variation of MMP can affect male infertility. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
ابوذر محققی | aboozar mohagheghi
student research committee, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
ایرج خدادادی | iraj khodadadi
department of biochemistry, faculty of medicine, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
منوچهر کرمی | manoochehr karami
modeling of non-communicable diseases research center, department of biostatistics and epidemiology, school of public health, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
ایرج امیری | iraj amiri
research center for endometr and endometriosis, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
حیدر طویلانی | heidar tavilani
urology and nephrology research center, hamadan university of medical sciences, hamadan, ir iran; urology and nephrology research center, hamadan university of medical sciences, hamadan, ir iran. tel 98-8138380462, fax 98-8138380208
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
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| نشانی اینترنتی |
http://www.avicennajb.com/index.php?page=article&article_id=27826 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
10.17795/ajmb-27826 |
| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
research-article |
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