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Avicenna Journal of Medical Biochemistry، جلد ۱، شماره ۱، صفحات ۳۰-۳۵
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| عنوان فارسی |
The arsR gene: A comparative phylogenetic and bioinformatics analysis to study reasons for different sensitivity to arsenic compounds |
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| چکیده فارسی مقاله |
Objectives The overall goal of this study was to carry out a set of comparative analyses of arsR gene in plasmid R773 and bacterial chromosome from Escherichia coli BL-21(DE3). Methods PDB and NCBI databases and Chimera, Mega4, CLC main workbench software and 3D-jigsaw and EMBL-EBI servers were applied to perform this study. By using these software and servers, multiple analyses including determination of residue composition, secondary structure and motifs, 3D structure, conserved regions, etc. were done. Results The results suggest that such high sensitivity to arsenic compounds in ars-containing plasmid R773 may be related to ArsR protein characteristics such as amino acids composition, secondary and tertiary structure, hy-drophobicity, level of interaction with DNA. Conclusion Bioinformatics studies could be applied to describe the reason of different sensitivities to Arsenic compounds between arsR gene and ArsR protein in plasmid R773 and bacterial chromosome. |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
The arsR gene: A comparative phylogenetic and bioinformatics analysis to study reasons for different sensitivity to arsenic compounds |
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| چکیده انگلیسی مقاله |
Objectives The overall goal of this study was to carry out a set of comparative analyses of arsR gene in plasmid R773 and bacterial chromosome from Escherichia coli BL-21(DE3). Methods PDB and NCBI databases and Chimera, Mega4, CLC main workbench software and 3D-jigsaw and EMBL-EBI servers were applied to perform this study. By using these software and servers, multiple analyses including determination of residue composition, secondary structure and motifs, 3D structure, conserved regions, etc. were done. Results The results suggest that such high sensitivity to arsenic compounds in ars-containing plasmid R773 may be related to ArsR protein characteristics such as amino acids composition, secondary and tertiary structure, hy-drophobicity, level of interaction with DNA. Conclusion Bioinformatics studies could be applied to describe the reason of different sensitivities to Arsenic compounds between arsR gene and ArsR protein in plasmid R773 and bacterial chromosome. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
مریم دانشپور | maryam daneshpour
department of molecular medicine and human genetics, school of medicine,hamadan university of medical sciences hamadan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
نوشین شباب | nooshin shabab
research center for molecular medicine, hamadan university of medical sciences, hamadan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
مسعود سعیدی جم | massoud saidijam
research center for molecular medicine, hamadan university of medical sciences, hamadan, iran; research center for molecular medicine, hamadan university of medical sciences, hamadan, iran , 98 9121324616
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
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| نشانی اینترنتی |
http://www.avicennajb.com/index.php?page=article&article_id=19875 |
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| زبان مقاله منتشر شده |
fa |
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| نوع مقاله منتشر شده |
research-article |
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