| چکیده فارسی مقاله |
Conclusions These results suggest a negative correlation between MDMA administration and adult hippocampal neurogenesis. Results Our results showed that MDMA administration caused a decrease in NeuN expression in the experimental group compared with the control group. Objectives Due to the effect of neurogenesis on memory and learning, in this study, we investigated the effects of MDMA on NeuN expression (a marker of neurogenesis) in the hippocampus. Methods Adult male Wistar rats (weighing 200 - 250 g) received a single intraperitoneal dose of 10 mg/kg of MDMA or were left undisrupted. The expression of NeuN was assessed using the immunohistochemistry method 7, 14, 28, and 60 days following MDMA administration. Background The administration of 3-4-methylenedioxymethamphetamine (MDMA) leads to learning and memory impairment. |
| چکیده انگلیسی مقاله |
Conclusions These results suggest a negative correlation between MDMA administration and adult hippocampal neurogenesis. Results Our results showed that MDMA administration caused a decrease in NeuN expression in the experimental group compared with the control group. Objectives Due to the effect of neurogenesis on memory and learning, in this study, we investigated the effects of MDMA on NeuN expression (a marker of neurogenesis) in the hippocampus. Methods Adult male Wistar rats (weighing 200 - 250 g) received a single intraperitoneal dose of 10 mg/kg of MDMA or were left undisrupted. The expression of NeuN was assessed using the immunohistochemistry method 7, 14, 28, and 60 days following MDMA administration. Background The administration of 3-4-methylenedioxymethamphetamine (MDMA) leads to learning and memory impairment. |
| نویسندگان مقاله |
fahimeh ghasemi moravej - cell therapy division of endometrium and endometriosis research center, hamadan university of medical sciences, hamadan, ir iran; anatomy department, school of medicine, hamadan university of medical sciences, hamadan, ir iran
iraj amiri - cell therapy division of endometrium and endometriosis research center, hamadan university of medical sciences, hamadan, ir iran; anatomy department, school of medicine, hamadan university of medical sciences, hamadan, ir iran
siamak shahidi - neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran
mehdi mehdizadeh - faculty of advanced technologies in medicine, cellular and molecular research center, iran university of medical sciences, tehran, ir iran
asrin rahimi - anatomy department, school of medicine, hamadan university of medical sciences, hamadan, ir iran
banafsheh esmaeilzadeh - faculty of medicine, anatomy department, bushehr university of medical sciences, bushehr, ir iran
sara soleimani asl - cell therapy division of endometrium and endometriosis research center, hamadan university of medical sciences, hamadan, ir iran; anatomy department, school of medicine, hamadan university of medical sciences, hamadan, ir iran; cell therapy division of endometrium and endometriosis research center, hamadan university of medical sciences, hamadan, ir iran. tel fax 98-8118380208
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