| چکیده فارسی مقاله |
Conclusions These results suggest a negative correlation between MDMA administration and adult hippocampal neurogenesis. Results Our results showed that MDMA administration caused a decrease in NeuN expression in the experimental group compared with the control group. Objectives Due to the effect of neurogenesis on memory and learning, in this study, we investigated the effects of MDMA on NeuN expression (a marker of neurogenesis) in the hippocampus. Methods Adult male Wistar rats (weighing 200 - 250 g) received a single intraperitoneal dose of 10 mg/kg of MDMA or were left undisrupted. The expression of NeuN was assessed using the immunohistochemistry method 7, 14, 28, and 60 days following MDMA administration. Background The administration of 3-4-methylenedioxymethamphetamine (MDMA) leads to learning and memory impairment. |
| چکیده انگلیسی مقاله |
Conclusions These results suggest a negative correlation between MDMA administration and adult hippocampal neurogenesis. Results Our results showed that MDMA administration caused a decrease in NeuN expression in the experimental group compared with the control group. Objectives Due to the effect of neurogenesis on memory and learning, in this study, we investigated the effects of MDMA on NeuN expression (a marker of neurogenesis) in the hippocampus. Methods Adult male Wistar rats (weighing 200 - 250 g) received a single intraperitoneal dose of 10 mg/kg of MDMA or were left undisrupted. The expression of NeuN was assessed using the immunohistochemistry method 7, 14, 28, and 60 days following MDMA administration. Background The administration of 3-4-methylenedioxymethamphetamine (MDMA) leads to learning and memory impairment. |
| نویسندگان مقاله |
فهیمه قاسمی مروج | fahimeh ghasemi moravej
cell therapy division of endometrium and endometriosis research center, hamadan university of medical sciences, hamadan, ir iran; anatomy department, school of medicine, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
ایرج امیری | iraj amiri
cell therapy division of endometrium and endometriosis research center, hamadan university of medical sciences, hamadan, ir iran; anatomy department, school of medicine, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
سیامک شهیدی | siamak shahidi
neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
مهدی مهدی زاده | mehdi mehdizadeh
faculty of advanced technologies in medicine, cellular and molecular research center, iran university of medical sciences, tehran, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)
اسرین رحیمی | asrin rahimi
anatomy department, school of medicine, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
بنفشه اسماعیل زاده | banafsheh esmaeilzadeh
faculty of medicine, anatomy department, bushehr university of medical sciences, bushehr, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بوشهر (Bushehr university of medical sciences)
سارا سلیمانی اصل | sara soleimani asl
cell therapy division of endometrium and endometriosis research center, hamadan university of medical sciences, hamadan, ir iran; anatomy department, school of medicine, hamadan university of medical sciences, hamadan, ir iran; cell therapy division of endometrium and endometriosis research center, hamadan university of medical sciences, hamadan, ir iran. tel fax 98-8118380208
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
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