Avicenna Journal of Neuro Psycho Phyisology، جلد ۲، شماره ۴، صفحات ۰-۰
عنوان فارسی Acute/Chronic Pain Relief: Is Althaea officinalis Essential Oil Effective?
چکیده فارسی مقاله Conclusions EOAO showed an analgesic effect that may involve both the central and peripheral nervous systems. Background The Althaea officinalis (marshmallow) plant is traditionally used to treat skin burns and constipation and to reduce inflammation. Objectives The aim of this study was to evaluate the acute and chronic analgesic effects of the essential oil of Althaea officinalis leaves (EOAO) in adult male mice. Materials and Methods This experimental study used thirty-six adult male mice, which were randomly divided into six groups: a control, three groups treated with EOAO (18, 38, or 80 mg/kg, i.p.), a morphine group (1 mg/kg, i.p.), and a group treated with a combination of naloxone (1 mg/kg, i.p.) and 80 mg/kg EOAO. The analgesic effects of EOAO were evaluated by writhing, tail-flick, and formalin tests. The essential oil of the plant was prepared by the steady distillation method and its composition was analyzed by GC/MS. Results Significant antinociceptive effects were noted with doses of 38 and 80 mg/kg EOAO in the chronic phase response of the formalin test (P < 0.05 versus control). Doses of 38 and 80 mg/kg EOAO had a significant analgesic effect in the writhing test (P < 0.05 and P < 0.01, respectively, versus control). The 80 mg/kg dose of EOAO caused an enhancement in reaction time in the tail-flick test (P < 0.01 versus control).
کلیدواژه‌های فارسی مقاله Medicinal Herb،Pain،Essential Oil،Mouse،Althaea officinalis
عنوان انگلیسی Acute/Chronic Pain Relief: Is Althaea officinalis Essential Oil Effective?
چکیده انگلیسی مقاله Conclusions EOAO showed an analgesic effect that may involve both the central and peripheral nervous systems. Background The Althaea officinalis (marshmallow) plant is traditionally used to treat skin burns and constipation and to reduce inflammation. Objectives The aim of this study was to evaluate the acute and chronic analgesic effects of the essential oil of Althaea officinalis leaves (EOAO) in adult male mice. Materials and Methods This experimental study used thirty-six adult male mice, which were randomly divided into six groups: a control, three groups treated with EOAO (18, 38, or 80 mg/kg, i.p.), a morphine group (1 mg/kg, i.p.), and a group treated with a combination of naloxone (1 mg/kg, i.p.) and 80 mg/kg EOAO. The analgesic effects of EOAO were evaluated by writhing, tail-flick, and formalin tests. The essential oil of the plant was prepared by the steady distillation method and its composition was analyzed by GC/MS. Results Significant antinociceptive effects were noted with doses of 38 and 80 mg/kg EOAO in the chronic phase response of the formalin test (P < 0.05 versus control). Doses of 38 and 80 mg/kg EOAO had a significant analgesic effect in the writhing test (P < 0.05 and P < 0.01, respectively, versus control). The 80 mg/kg dose of EOAO caused an enhancement in reaction time in the tail-flick test (P < 0.01 versus control).
کلیدواژه‌های انگلیسی مقاله Medicinal Herb,Pain,Essential Oil,Mouse,Althaea officinalis
نویسندگان مقاله یوسف گلشنی | yosef golshani
department of biology, payam-noor university, hamadan branch, hamadan, ir iran


محمد زارعی | mohammad zarei
neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran; neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran. tel 98-8138380462, fax 98-8138380464

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

سعید محمدی | saeed mohammadi
department of biology, hamadan branch, islamic azad university, hamadan, ir iran; department of biology, hamadan branch, islamic azad university, hamadan, ir iran. tel 98-9187134858, fax 98-8138380464

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

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کد مقاله (doi) 10.17795/ajnpp-36586
زبان مقاله منتشر شده fa
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نوع مقاله منتشر شده research-article
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