|
|
Avicenna Journal of Neuro Psycho Phyisology، جلد ۲، شماره ۴، صفحات ۰-۰
|
|
|
| عنوان فارسی |
Effect of Magnesium Oxide Nanoparticles on Atropine-Induced Memory Impairment in Adult Male Mice |
|
| چکیده فارسی مقاله |
Materials and Methods In this experimental study, NMRI male mice were placed in groups receiving atropine (0.1 and 1 mg/kg), recipient of MgO-n (1, 2.5, and 5 mg/kg) and groups receiving atropine in effective dose and different doses of MgO-n were used. Saline was used as a vehicle for drugs in the control groups. Memory was evaluated with a step-down apparatus to determine the coming down latency from a safe platform on days 1, 3, and 7 after training. Locomotor activity was also evaluated through an open field test in all groups after memory measurements. Results The results showed that atropine (1 mg/kg) decreased the latency time of coming down from the podium and induced memory deficits (P < 0.01). MgO-n in doses of 2.5 and 5 mg/kg caused a significant increase in latency time of coming down from the podium over one week (P < 0.001). MgO-n was able to reverse memory impairments resulting from atropine (1 mg/kg) (P < 0.001). Locomotor activity did not change in any of the groups. Conclusions It seems that the potentiating effect of MgO-n on memory is due to interference with the cholinergic pathway. Background Previous studies have shown that magnesium oxide nanoparticles (MgO-n) improve passive avoidance memory in adult male mice. Alternatively, muscarinic receptors of the cholinergic system have a primary role in memory formation but their relationship with the improvement effects of magnesium on memory is not clear. Objectives The aim of this study was to investigate the effect of nano magnesium oxide on memory deficits induced by atropine as a muscarinic receptor antagonist in passive avoidance memory tests. |
|
| کلیدواژه‌های فارسی مقاله |
Atropine،Magnesium،Memory،Nanoparticles |
|
| عنوان انگلیسی |
Effect of Magnesium Oxide Nanoparticles on Atropine-Induced Memory Impairment in Adult Male Mice |
|
| چکیده انگلیسی مقاله |
Materials and Methods In this experimental study, NMRI male mice were placed in groups receiving atropine (0.1 and 1 mg/kg), recipient of MgO-n (1, 2.5, and 5 mg/kg) and groups receiving atropine in effective dose and different doses of MgO-n were used. Saline was used as a vehicle for drugs in the control groups. Memory was evaluated with a step-down apparatus to determine the coming down latency from a safe platform on days 1, 3, and 7 after training. Locomotor activity was also evaluated through an open field test in all groups after memory measurements. Results The results showed that atropine (1 mg/kg) decreased the latency time of coming down from the podium and induced memory deficits (P < 0.01). MgO-n in doses of 2.5 and 5 mg/kg caused a significant increase in latency time of coming down from the podium over one week (P < 0.001). MgO-n was able to reverse memory impairments resulting from atropine (1 mg/kg) (P < 0.001). Locomotor activity did not change in any of the groups. Conclusions It seems that the potentiating effect of MgO-n on memory is due to interference with the cholinergic pathway. Background Previous studies have shown that magnesium oxide nanoparticles (MgO-n) improve passive avoidance memory in adult male mice. Alternatively, muscarinic receptors of the cholinergic system have a primary role in memory formation but their relationship with the improvement effects of magnesium on memory is not clear. Objectives The aim of this study was to investigate the effect of nano magnesium oxide on memory deficits induced by atropine as a muscarinic receptor antagonist in passive avoidance memory tests. |
|
| کلیدواژه‌های انگلیسی مقاله |
Atropine,Magnesium,Memory,Nanoparticles |
|
| نویسندگان مقاله |
زینب سرقلی نوترکی | zeinab sargholi nootarki
department of biology, faculty of science, shahid chamran university, ahvaz, ir iran
سازمان اصلی تایید شده: دانشگاه شهید چمران (Shahid chamran university)
مهناز کسمتی | mahnaz kesmati
department of biology, faculty of science, shahid chamran university, ahvaz, ir iran; department of biology, faculty of science, shahid chamran university, ahvaz, ir iran. tel 98-9166126897
سازمان اصلی تایید شده: دانشگاه شهید چمران (Shahid chamran university)
مهدی پورمهدی بروجنی | mahdi poormehdi borujeni
department of food hygiene, shahid chamran university, ahvaz, ir iran
سازمان اصلی تایید شده: دانشگاه شهید چمران (Shahid chamran university)
|
|
| نشانی اینترنتی |
http://www.avicennajnpp.com/index.php?page=article&article_id=36924 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
10.17795/ajnpp-36924 |
| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
|
| نوع مقاله منتشر شده |
research-article |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|