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Avicenna Journal of Neuro Psycho Phyisology، جلد ۱، شماره ۱، صفحات ۰-۰
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| عنوان فارسی |
Effect of Amyloid β- Peptide on Passive Avoidance Learning in Rats: A Behavioral Study |
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| چکیده فارسی مقاله |
Conclusions These data suggest that single bilateral microinjection of Aβ (25-35) could impair memory and can be used as an AD model in Wistar rats. Results The results showed that Aβ (25-35) significantly impaired both step-through latency and time in dark compartment in the passive avoidance task. Background Alzheimer's disease (AD) is the most common form of dementia that leads to neurotoxicity. Amyloid β-peptide (Aβ) has a pivotal role in the pathogenesis of AD. Objective Given the contradictory results of Aβ (25-35) on the memory, in the present study we have examined the effect of Aβ - induced memory impairment. Materials and Methods Wistar male rats received an intrahippocampal (IHP) injection of Aβ (25-35).The learning function in the rats was examined by the passive avoidance task. |
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| کلیدواژههای فارسی مقاله |
Alzheimer&apos،s disease، Amyloid β-peptide، Learning، Rats |
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| عنوان انگلیسی |
Effect of Amyloid β- Peptide on Passive Avoidance Learning in Rats: A Behavioral Study |
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| چکیده انگلیسی مقاله |
Conclusions These data suggest that single bilateral microinjection of Aβ (25-35) could impair memory and can be used as an AD model in Wistar rats. Results The results showed that Aβ (25-35) significantly impaired both step-through latency and time in dark compartment in the passive avoidance task. Background Alzheimer's disease (AD) is the most common form of dementia that leads to neurotoxicity. Amyloid β-peptide (Aβ) has a pivotal role in the pathogenesis of AD. Objective Given the contradictory results of Aβ (25-35) on the memory, in the present study we have examined the effect of Aβ - induced memory impairment. Materials and Methods Wistar male rats received an intrahippocampal (IHP) injection of Aβ (25-35).The learning function in the rats was examined by the passive avoidance task. |
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| کلیدواژههای انگلیسی مقاله |
Alzheimer&apos,s disease, Amyloid β-peptide, Learning, Rats |
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| نویسندگان مقاله |
علی نیکخواه | ali nikkhah
neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
فاطمه ghahremanitamadon | fatemeh ghahremanitamadon
neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
سمیه zargooshnia | somayeh zargooshnia
neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
سیامک شهیدی | siamak shahidi
neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
سارا سلیمانی اصل | sara soleimani asl
neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran; department of anatomy, hamadan university of medical sciences, hamadan, ir iran; neurophysiology research center, hamadan university of medical sciences, hamadan, ir iran, tel fax 98-8118380208
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
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| نشانی اینترنتی |
http://www.avicennajnpp.com/index.php?page=article&article_id=18664 |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
10.17795/ajnpp-18664 |
| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
research-article |
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