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Avicenna Journal of Clinical Microbiology and Infection، جلد 1، شماره 3، صفحات 0-0
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| عنوان فارسی |
Prevalence of Extended Spectrum β-Lactamase in Klebsiella pneumonia Isolates in a Teaching Hospital of Zahedan City, Iran |
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| چکیده فارسی مقاله |
Background Extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumonia has become widespread in hospitals and is increasing in community settings. Most of K. pneumonia that harbor these enzymes, display resistance to other unrelated antimicrobial agents and thus, often pose a therapeutic dilemma. Objectives This study was conducted to determine the prevalence of ESBL-producing K. pneumonia in a major university hospital in Zahedan, Iran. Materials and Methods The susceptibility of 83 K. pneumonia isolates to 12 antibiotics was assessed using Kirby-Bauer disc diffusion method. For the ESBL phenotypic test, double-disk diffusion (DD) method was used. Results The highest resistance rates of the isolates were seen against cefixime (82%), cefotaxime (81%), ceftriaxone (73%), ceftazidime (72%), and azithromycin (60%), consecutively. The lowest resistance rates were observed against gentamicin (58%), tetracycline (59%), nalidixic acid (59%), and amikacin (63%), consecutively. ESBLs were found in 65% of K. pneumonia isolates. Conclusions We found that 65% of K. pneumonia isolates produced ESBL. Therapeutic strategies to control infections should be carefully formulated in teaching hospitals. The high percentage of drug resistance in ESBL-producing K. pneumonia suggests that routine detection of ESBL by reliable laboratory methods is required. |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Prevalence of Extended Spectrum β-Lactamase in Klebsiella pneumonia Isolates in a Teaching Hospital of Zahedan City, Iran |
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| چکیده انگلیسی مقاله |
Background Extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumonia has become widespread in hospitals and is increasing in community settings. Most of K. pneumonia that harbor these enzymes, display resistance to other unrelated antimicrobial agents and thus, often pose a therapeutic dilemma. Objectives This study was conducted to determine the prevalence of ESBL-producing K. pneumonia in a major university hospital in Zahedan, Iran. Materials and Methods The susceptibility of 83 K. pneumonia isolates to 12 antibiotics was assessed using Kirby-Bauer disc diffusion method. For the ESBL phenotypic test, double-disk diffusion (DD) method was used. Results The highest resistance rates of the isolates were seen against cefixime (82%), cefotaxime (81%), ceftriaxone (73%), ceftazidime (72%), and azithromycin (60%), consecutively. The lowest resistance rates were observed against gentamicin (58%), tetracycline (59%), nalidixic acid (59%), and amikacin (63%), consecutively. ESBLs were found in 65% of K. pneumonia isolates. Conclusions We found that 65% of K. pneumonia isolates produced ESBL. Therapeutic strategies to control infections should be carefully formulated in teaching hospitals. The high percentage of drug resistance in ESBL-producing K. pneumonia suggests that routine detection of ESBL by reliable laboratory methods is required. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
mahbobeh barakzahi - department of biology, faculty of basic sciences, university of zabol, zabol, ir iran
bahman hormozi - department of biology, faculty of basic sciences, university of zabol, zabol, ir iran
ahmad rashki - department of physiopathology, faculty of veterinary medicine, university of zabol, zabol, ir iran; department of physiopathology, faculty of veterinary medicine, university of zabol, zabol, ir iran. tel 98-9151970877, fax 98-5422240735
zahra rashki ghalehnoo - departments of microbiology and parasitology, faculty of medicine, zabol university of medical sciences, zabol, ir iran
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| نشانی اینترنتی |
http://www.ajcmicrob.com/index.php?page=article&article_id=22934 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/1795/article-1795-276841.pdf |
| کد مقاله (doi) |
10.17795/ajcmi-22934 |
| زبان مقاله منتشر شده |
fa |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
research-article |
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