Journal of Research in Health Sciences، جلد ۱۷، شماره ۴، صفحات ۰-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The Effect of Various Stabilizers on Preserving Immunogenicity of Lyophilized Mumps Vaccines
چکیده انگلیسی مقاله Background: Chemical stabilizers are added to live attenuated vaccines for enhancing the virus stability. The aim of this study was to evaluate the effect of various stabilizers on preserving immunogenicity of lyophilized mumps vaccines. Study design: An experimental study. Methods: Three mumps vaccines with different formulations were inoculated to three groups of Guinea pigs. Sterile water was injected to eight Guinea pigs as a control group. Blood samples were collected before inoculation and on 14, 28 and 42 d after vaccine injection. Mumps antibodies in the sera were measured using hemagglutination inhibition assay (HAI). Results: All three formulated mumps vaccines induced antibody in Guinea pigs after two weeks. Formulation 1 containing trehalose dihydrate and formulation 2 comprised human serum albumin stimulated antibodies in the higher level than Razi routine formulation. Conclusions: Various stabilizers have different preservation potencies that differently affect immune response against virus. More stable and more immunogenic vaccines can be produced using stabilizers containing trehalose dihydrate.
کلیدواژه‌های انگلیسی مقاله Immunogenicity,Vaccine,Mumps Virus
نویسندگان مقاله راضیه کمالی جمیل | razieh kamali jamil


محمد shayestehour | mohammad shayestehour


زهره آزیتا صدیق | zohreh azita sadigh


محمد تقویان | mohammad taqavian


محمد کاظم شاه کرمی | mohammad kazem shahkarami


فاطمه اثنی عشری | fatemeh esna ashari


رضا شهبازی | reza shahbazi


اشرف محمدی | ashraf mohammadi


ابوالحسن فروغی | abolhassan foroughi


بیژن رومانی | bizhan romani


نشانی اینترنتی http://jrhs.umsha.ac.ir/index.php/JRHS/article/view/3368
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/135/article-135-433231.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Short Communications
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