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Journal of Research in Health Sciences، جلد ۱۴، شماره ۲، صفحات ۱۳۶-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژههای فارسی مقاله |
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| عنوان انگلیسی |
Evaluation of IFN-γ Polymorphism in Visceral Leishmaniasis |
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| چکیده انگلیسی مقاله |
Background: Leishmaniasis is a tropical disease that is endemic in some areas of Iran, including East Azerbaijan . IFN-γ is one of the cytokines that triggers cell-mediated immunity, thus initiating elimination of the infection. This case-control study was performed to investigate the association between the polymorphism of the IFN-γ gene at the +874A/T locus and visceral leishmaniasis (VL). Methods: In this study conducted during 2012-2013, 267 participants were selected from individuals living in an endemic area of VL. Subjects were divided into three groups; 86 patients with VL, 82 seropositive individuals without any history of leishmaniasis, and 99 seronegative healthy controls. Genotyping of the IFN-γ +874A/T polymorphism was carried out using an Amplification Refractory Mutation System-PCR (ARMS-PCR). Results: The frequency of the +874A allele in the patient group (75.5%) was higher than in the seropositive individuals (54%). The highest frequency of the +874 T / T genotype was observed in seropositive individuals, while the patient group had the lowest frequency (34.1% vs. 24.5%) . However, these differences were not significant. Conclusion: There was no significant association between IFN- γ +874A/T polymorphism and VL. |
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| کلیدواژههای انگلیسی مقاله |
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| نویسندگان مقاله |
امیرحسین مقصود | amir hossein maghsood
غلامرضا جدیداسلام | golamreza jadideslam
محمد فلاح | mohammad fallah
احد بازمانی | ahad bazmani
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| نشانی اینترنتی |
http://journals.umsha.ac.ir/index.php/JRHS/article/view/1106 |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Articles |
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