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Avicenna Journal of Neuro Psycho Phyisology، جلد ۲، شماره ۱، صفحات ۲۵-۲۹
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
In Vivo Antinociceptive Effects of Persian Shallot (Alliumhirtifolium) in Male Rat |
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| چکیده انگلیسی مقاله |
Background: The tendency toward using herbal plants instead of synthetic drugs is increasing in recent years because of their lower adverse effects and high varieties of efficient components. Objectives: In this investigation, analgesic effects of hydroalcoholic leaf extract of Alliumhirtifolium were studied in male rats. Materials and Methods: A total of 48 adult male rats were divided eight groups: control, intraperitoneal 50, 100, and 200 mg/kg of extract, 200 mg/kg of A.hirtifolium extract plus aspirin, aspirin (1 mg/kg), morphine (1 mg/kg), and 200 mg/kg of A.hirtifolium extract plus naloxone (1 mg/kg). The analgesic effects of A.hirtifolium were assessed with writhing, tail-flick, and formalin tests. The data were compared with control by one-way ANOVA and Tukey post hoc test. Results: Alliumhirtifolium extract at (200 mg/kg dosage), alone and in combination with aspirin, had shown antinociceptive effect in writhing, tail-flick, and formalin tests (P < 0.01). Alliumhirtifolium extract (at 100 mg/kg dosage) had just shown analgesic effects on tail-flick and formalin (chronic phase) tests. Conclusions: It looks that A. hirtifolium has antinociceptive effects that might be due to flavonoids and saponins in plant the analgesic effect of which was demonstrated previously. |
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| کلیدواژه‌های انگلیسی مقاله |
Allium hirtifolium, Formaldehyde, Saponins, Flavonoids |
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| نویسندگان مقاله |
| Saeed Mohammadi
Biology Department, Faculty of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, IR Iran
| Mohammad Zarei
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran ; Physiology Department, Medicine Faculty, Hamadan University of Medical Sciences, Hamadan, IR Iran
| Minoo Mahmoodi
Biology Department, Faculty of Basic Sciences, Hamadan Branch, Islamic Azad University, Hamadan, IR Iran
| Mohammad Mahdi Zarei
Veterinary Medicine Faculty, Karaj Branch, Islamic Azad University, Karaj, IR Iran
| Mahtab Asgari Nematian
Biology Department, Hamadan Branch, Payam-Noor University, Hamadan, IR Iran
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| نشانی اینترنتی |
http://ajnpp.umsha.ac.ir/browse.php?a_code=A-10-2-22&slc_lang=en&sid=1 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/363/article-363-701906.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
تخصصی |
| نوع مقاله منتشر شده |
پژوهشی |
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