Avicenna Journal of Clinical Microbiology and Infection، جلد ۴، شماره ۱، صفحات ۰-۰
عنوان فارسی Tuberculosis and Vitamin D Status Among the Contacts of Pulmonary Tuberculosis Patients
چکیده فارسی مقاله Conclusions Our results suggest that a sufficient VitD level could be a protective factor against TBIC and active TB. Background Serum vitamin D (VitD) status is associated with active tuberculosis (TB) and TB infection conversion (TBIC). Objectives The objective of the present study was to quantify the risks of TB (latent, conversion, disease) in accordance with VitD status and other variables among the contacts of pulmonary TB patients. Methods From 2009 to 2012, a cohort of the contacts of pulmonary TB patients was studied to rule out and prevent TB in Castellon (Spain). The exams performed included a tuberculin skin test (TST), a QuantiFERON Gold in-tube test® (QFTGIT), blood and radiographic tests, and an initial measurement of serum VitD status. Contacts who were initially without active TB were followed up through 2015. Multinomial logistic regression (MLR) analyses were carried out. Results From a total of 572 contacts of pulmonary TB patients with VitD status measurement, 523 completed the follow-up (participation rate 91.4%). Among them, five groups could be established: 3 new cases of pulmonary TB (0.6%), 27 cases of TBIC (5.2%), 116 cases of latent TB infection (LTBI) (22.2%), 125 uninfected TB contacts with only one TST or QFTGIT measurement (23.9%), and 252 uninfected TB contacts with two TST or QFTGIT measurements (48.2%). The comparison of these five groups revealed several significant differences, including age, whether they were foreign-born, place of residence, social class, high exposure to an index case with sputum acid-fast bacilli (AFB), and VitD status. The MLR analysis for all groups, with the group of uninfected TB contacts with two TST or QFTGIT measurements as a reference, estimated that only two of these factors were significantly associated with TB in three or more groups; these factors were VitD status and high exposure and a sputum AFB-positive index case. VitD status was a protector against pulmonary TB with a relative risk (RR) of 0.86 (95% confidence interval [CI] 0.74 - 0.99) and against TBIC (R = 0.95; 95% CI 0.91 - 0.99), while it was not associated with LTBI (RR = 0.99; 95% CI 0.97-1.01). Only 34.0% of the contacts had sufficient VitD levels (≥ 30 ng/mL).
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عنوان انگلیسی Tuberculosis and Vitamin D Status Among the Contacts of Pulmonary Tuberculosis Patients
چکیده انگلیسی مقاله Conclusions Our results suggest that a sufficient VitD level could be a protective factor against TBIC and active TB. Background Serum vitamin D (VitD) status is associated with active tuberculosis (TB) and TB infection conversion (TBIC). Objectives The objective of the present study was to quantify the risks of TB (latent, conversion, disease) in accordance with VitD status and other variables among the contacts of pulmonary TB patients. Methods From 2009 to 2012, a cohort of the contacts of pulmonary TB patients was studied to rule out and prevent TB in Castellon (Spain). The exams performed included a tuberculin skin test (TST), a QuantiFERON Gold in-tube test® (QFTGIT), blood and radiographic tests, and an initial measurement of serum VitD status. Contacts who were initially without active TB were followed up through 2015. Multinomial logistic regression (MLR) analyses were carried out. Results From a total of 572 contacts of pulmonary TB patients with VitD status measurement, 523 completed the follow-up (participation rate 91.4%). Among them, five groups could be established: 3 new cases of pulmonary TB (0.6%), 27 cases of TBIC (5.2%), 116 cases of latent TB infection (LTBI) (22.2%), 125 uninfected TB contacts with only one TST or QFTGIT measurement (23.9%), and 252 uninfected TB contacts with two TST or QFTGIT measurements (48.2%). The comparison of these five groups revealed several significant differences, including age, whether they were foreign-born, place of residence, social class, high exposure to an index case with sputum acid-fast bacilli (AFB), and VitD status. The MLR analysis for all groups, with the group of uninfected TB contacts with two TST or QFTGIT measurements as a reference, estimated that only two of these factors were significantly associated with TB in three or more groups; these factors were VitD status and high exposure and a sputum AFB-positive index case. VitD status was a protector against pulmonary TB with a relative risk (RR) of 0.86 (95% confidence interval [CI] 0.74 - 0.99) and against TBIC (R = 0.95; 95% CI 0.91 - 0.99), while it was not associated with LTBI (RR = 0.99; 95% CI 0.97-1.01). Only 34.0% of the contacts had sufficient VitD levels (≥ 30 ng/mL).
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نویسندگان مقاله آلبرتو arnedo pena | alberto arnedo pena
epidemiology division, public health centre castellon, spain; ciber of epidemiology and public health ciberesp , barcelona, spain; epidemiology division, public health centre castellon, spain. tel 34-964399607, fax 34-064399645


خوزه vicente خوان cerdan | jose vicente juan cerdan
biochemical laboratory, hospital general, castellon, spain


ماریا angeles romeu گارسیا | maria angeles romeu garcia
epidemiology division, public health centre castellon, spain


دانیال گارسیا فرر | daniel garcia ferrer
biochemical laboratory, hospital general, castellon, spain


عیسی iborra millet | jesus iborra millet
biochemical laboratory, hospital general, castellon, spain


خوزه آنتونیو ferrero وگا | jose antonio ferrero vega
biochemical laboratory, hospital general, castellon, spain


خوان bautista bellido blasco | juan bautista bellido blasco
epidemiology division, public health centre castellon, spain; ciber of epidemiology and public health ciberesp , barcelona, spain


noemi meseguer فرر | noemi meseguer ferrer
epidemiology division, public health centre castellon, spain


فرانسیسکو pardo serrano | francisco pardo serrano
microbiology laboratory, hospital general, castellon, spain
نشانی اینترنتی http://www.ajcmicrob.com/index.php?page=article&article_id=36889
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کد مقاله (doi) 10.17795/ajcmi-36889
زبان مقاله منتشر شده fa
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نوع مقاله منتشر شده research-article
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